Interleukin-33 deficiency exacerbated experimental autoimmune encephalomyelitis with an influence on immune cells and glia cells

Molecular Immunology
Yifan XiaoFang Zheng

Abstract

Interleukin (IL)-33, a member of the IL-1 cytokine family, is highly expressed in central nervous system (CNS), suggesting its potential role in CNS. Although some studies have focused on the role of IL-33 in multiple sclerosis (MS) / experimental autoimmune encephalomyelitis (EAE), an autoimmune disease characterized by demyelination and axonal damage in CNS, the exact role of IL-33 in MS/EAE remains unclear and controversial. Here, we used IL-33 knockout mice to clarify the role of endogenous IL-33 in EAE by simultaneously eliminating its role as a nuclear transcription factor and an extracellular cytokine. We found that the clinical score in IL-33 knockout EAE mice was higher accompanied by more severe demyelination compared with the wild-type (WT) EAE mice. As for the main immune cells participating in EAE in IL-33 knockout mice, pathogenic effector T cells increased both in peripheral immune organs and CNS, while CD4+FOXP3+ regulatory T cells decreased in spleen and lymph nodes, Th2 cells and natural killer (NK) cells decreased in CNS. Additionally, the populations of microglia/macrophages and CD11C+CD11B+ dendritic cells (DCs) increased in CNS of IL-33 knockout mice with EAE, among which iNOS-producing microglia/macrophag...Continue Reading

Citations

Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Åsa Ljunggren-RoseSubramaniam Sriram
Jun 30, 2019·The Journal of Pharmacology and Experimental Therapeutics·Louisane DesbiensPedro D'Orléans-Juste
Oct 24, 2020·The Journal of Experimental Medicine·Saskia HemmersAlexander Y Rudensky
Aug 28, 2020·The Journal of Investigative Dermatology·Fanfan ZengFang Zheng
Jun 4, 2021·Frontiers in Immunology·Yun SunXiaofeng Yang
Jun 22, 2021·International Reviews of Immunology·Kevin M HarrisLinda R Watkins

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