Interleukin 33 is a guardian of barriers and a local alarmin

Nature Immunology
Nikolas T Martin, Michael U Martin

Abstract

Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing number of target cells and a plethora of biological functions. Although it has commonalities with other IL-1 cytokines, IL-33 exhibits some unique features. Here we review the biology of IL-33 and its receptor and develop a working model that describes two 'lives' for IL-33-one intracellular and one extracellular. Under healthy conditions, constitutively produced, intracellular IL-33 participates in maintaining barrier function by regulating gene expression as a nuclear protein. In parallel, nuclear IL-33 functions as a stored alarmin that is released when barriers are breached. Extracellular IL-33 coordinates immune defense and repair mechanisms while also initiating differentiation of helper T cells as the adaptive immune response is triggered.

References

Sep 1, 1992·Molecular and Cellular Biology·A LanahanD Nathans
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G Superti-FurgaM Busslinger
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R KlemenzA K Werenskiold
Mar 28, 1998·The Journal of Experimental Medicine·D XuF Y Liew
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·M LöhningT Kamradt
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H OndaJ Takeda
Mar 23, 2000·The Journal of Experimental Medicine·M J TownsendA N McKenzie
Jun 24, 2003·The American Journal of Pathology·Espen S BaekkevoldJean-Philippe Girard
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Virginie CarriereJean-Philippe Girard
May 12, 2007·The Journal of Clinical Investigation·Shoji SanadaRichard T Lee
Jul 12, 2007·The Journal of Biological Chemistry·Hiroko HayakawaShin-ichi Tominaga
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alissa A ChackerianRobert A Kastelein
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shafaqat AliMichael U Martin
Jun 17, 2008·Journal of Leukocyte Biology·Chad A HudsonPaul T Massa
Aug 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Damo XuFoo Y Liew
Feb 28, 2009·Arthritis and Rheumatism·Gaby PalmerCem Gabay
Apr 11, 2009·Trends in Immunology·Guttorm HaraldsenAxel M Küchler
Apr 14, 2009·The Journal of Allergy and Clinical Immunology·Matthew A RankHirohito Kita
Apr 28, 2009·Biochemical and Biophysical Research Communications·I Stuart WoodPaul Trayhurn
May 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Corinne Cayrol, Jean-Philippe Girard
May 26, 2009·The Journal of Biological Chemistry·Dominique Talabot-AyerGaby Palmer
Jun 11, 2009·Biochemical and Biophysical Research Communications·Xiaojin LiuTian Huang
Jun 30, 2009·Immunity·Alexander U LüthiSeamus J Martin
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Liying GuoWilliam Paul
Oct 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·David PréfontaineQutayba Hamid
Oct 31, 2009·European Journal of Immunology·Hēth R Turnquist, Angus W Thomson
Nov 17, 2009·Immunology Letters·Jakob Benedict SeidelinOle Haagen Nielsen
Nov 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tatsukuni OhnoSusumu Nakae
Dec 29, 2009·Biochemical and Biophysical Research Communications·Shafaqat AliMichael Uwe Martin
Jan 12, 2010·Current Opinion in Immunology·Anne F McGettrick, Luke A J O'Neill
Jan 15, 2010·Immunology·Christopher J NileJohn J Taylor
Jan 19, 2010·Nature Reviews. Immunology·Foo Y LiewIain B McInnes
Feb 16, 2010·The Journal of Allergy and Clinical Immunology·David PréfontaineQutayba Hamid
Mar 23, 2010·Cellular & Molecular Immunology·Weihua Zhao, Zhiqing Hu

❮ Previous
Next ❯

Citations

Jun 19, 2016·Arthritis Research & Therapy·Sara Khaleghparast AthariNatacha Bessis
Jan 25, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Carl D Richards
Mar 14, 2017·Nature Reviews. Immunology·Nader YatimMatthew L Albert
Apr 6, 2016·AIDS·Vikram MehrajUNKNOWN Montreal Primary HIV Infection, the Canadian Long-Term Non-Progressors Study Groups
Apr 28, 2017·PLoS Pathogens·Flora ReverchonValérie F J Quesniaux
Apr 1, 2017·Parasitology International·Takenori SekiNobuo Ohta
Apr 4, 2017·Parasite Immunology·K FilbeyG Le Gros
May 13, 2017·Expert Opinion on Therapeutic Targets·Judith AustermannJohannes Roth
May 10, 2017·The Journal of Allergy and Clinical Immunology·Hideaki MoritaKenji Matsumoto
Sep 24, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Miha LavricHelmut Wittkowski
Feb 24, 2017·Cell Reports·Simona SaluzzoSylvia Knapp
Dec 3, 2016·Seminars in Immunopathology·Dana ShikYui-Hsi Wang
Jun 29, 2017·Immunological Reviews·Li Yin Drake, Hirohito Kita
Jan 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Abigail E RussiMelissa A Brown
Apr 8, 2017·International Journal of Molecular Sciences·Wei-Yu ChenJenq-Lin Yang
Jan 9, 2018·Oncoimmunology·Gilda VarricchiGiovanna Schiavoni
Feb 9, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christopher deFilippiJanet Lo
Aug 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jaleesa M GarthChad Steele
Mar 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tor Espen Stav-NoraasJohanna Hol
Oct 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sebastian DrubeThomas Kamradt
Dec 17, 2017·Immunological Reviews·Diana BoraschiMichael U Martin
Dec 31, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christiane GöpfertSebastian Drube
Sep 23, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie BoudaudMarek Rola-Pleszczynski
Dec 6, 2018·International Journal of Molecular Sciences·Ivan PrestaGiuseppe Donato
Oct 21, 2018·Nature Reviews. Rheumatology·Zhu ChenGeorg Schett
Sep 2, 2018·Immunology and Cell Biology·Pierre C McCarthyJ Simon C Arthur
Dec 7, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mehdi NajarHassan Fahmi
Nov 5, 2017·Cold Spring Harbor Perspectives in Biology·Ajithkumar Vasanthakumar, Axel Kallies
Mar 29, 2019·International Journal of Environmental Research and Public Health·Elisabeth ØyaJørn A Holme
Aug 21, 2019·Nature Immunology·Diana BoraschiMichael U Martin
Jun 25, 2019·Frontiers in Immunology·Craig P McEnteeEd C Lavelle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Immunology
Guttorm HaraldsenAxel M Küchler
Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Song WangDong-Qing Ye
© 2022 Meta ULC. All rights reserved