Interleukin 33 Selectively Augments Rhinovirus-Induced Type 2 Immune Responses in Asthmatic but not Healthy People

Frontiers in Immunology
Lisa M JurakJohn W Upham

Abstract

Interleukin- 33 (IL-33) is an epithelial-derived cytokine that initiates type 2 immune responses to allergens, though whether IL-33 has the ability to modify responses to respiratory viral infections remains unclear. This study aimed to investigate the effects of IL-33 on rhinovirus (RV)-induced immune responses by circulating leukocytes from people with allergic asthma, and how this response may differ from non-allergic controls. Our experimental approach involved co-exposing peripheral blood mononuclear cells to IL-33 and RV in order to model how the functions of virus-responsive lymphocytes could be modified after recruitment to an airway environment enriched in IL-33. In the current study, IL-33 enhanced RV-induced IL-5 and IL-13 release by cells from people with allergic asthma, but had no effect on IL-5 and IL-13 production by cells from healthy donors. In asthmatic individuals, IL-33 also enhanced mRNA and surface protein expression of ST2 (the IL-33 receptor IL1RL1), while soluble ST2 concentrations were low. In contrast, IL-33 had no effect on mRNA and surface expression of ST2 in healthy individuals. In people with allergic asthma, RV-activated ST2+ innate lymphoid cells (ST2+ILC) were the predominant source of IL-33 ...Continue Reading

References

Jul 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C M AlperJ M Gwaltney
Apr 11, 2000·The Journal of Allergy and Clinical Immunology·D E ParryJ E Gern
Mar 30, 2002·Thorax·N G PapadopoulosS L Johnston
Aug 21, 2003·American Journal of Respiratory and Critical Care Medicine·G Daniel BrooksWilliam W Busse
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Simon D MessageSebastian L Johnston
Aug 1, 2009·The European Respiratory Journal·M RoponenJ W Upham
Jan 5, 2011·Respiratory Research·Melanie L CarrollJohn W Upham
Jun 7, 2011·American Journal of Respiratory Cell and Molecular Biology·Ronan Le GofficMichel Samson
Feb 6, 2013·The Journal of Allergy and Clinical Immunology·Néomi S GrotenboerMartijn C Nawijn
Feb 27, 2014·The Journal of Allergy and Clinical Immunology·Olga E SavenijeGerard H Koppelman
Aug 6, 2014·The Journal of Allergy and Clinical Immunology·Russell S TraisterSally E Wenzel
Oct 29, 2014·American Journal of Respiratory and Critical Care Medicine·David J JacksonSebastian L Johnston
Jan 27, 2015·The Journal of Allergy and Clinical Immunology·Christina A ChristiansonRafeul Alam
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Claudia BaumannMax Löhning
Aug 20, 2015·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Anil ChauhanNandini Paul
Nov 27, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Anna M ZoltowskaGunnar P Nilsson
Jan 20, 2016·Nature Immunology·Nikolas T Martin, Michael U Martin
Mar 8, 2016·The Journal of Allergy and Clinical Immunology·Vincent LombardiPhilippe Moingeon
Jun 25, 2016·The European Respiratory Journal·Emma DoranLiam G Heaney
Jul 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Erin D GordonJohn V Fahy
Aug 25, 2016·The Journal of Allergy and Clinical Immunology·Manuel A R FerreiraUNKNOWN Australian Asthma Genetics Consortium Collaborators
Oct 27, 2016·Nature Reviews. Immunology·Foo Yew LiewHeth Roderick Turnquist
Mar 7, 2017·Scientific Reports·Isabell HentschkeSusetta Finotto
Mar 10, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jiacheng BiXiaochun Wan
Jun 4, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew T StierR Stokes Peebles
Jun 6, 2017·The Journal of Allergy and Clinical Immunology·Hadi MaaziOmid Akbari
Dec 19, 2017·Frontiers in Immunology·Bobby W S LiRudi W Hendriks
Feb 22, 2018·American Journal of Respiratory and Critical Care Medicine·Adnan CustovicSebastian L Johnston

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Citations

Feb 7, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Arnaud BourdinPascal Chanez
Jan 8, 2021·Frontiers in Cell and Developmental Biology·Qianmin ChenDe-Yun Wang
May 23, 2020·The Journal of Allergy and Clinical Immunology·Maria E KetelaarMartijn C Nawijn
Apr 6, 2021·Pharmacology & Therapeutics·A K Saikumar JayalathaM C Nawijn

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Methods Mentioned

BETA
blood collection
ELISA
flow cytometry

Software Mentioned

Graphpad prism
FlowJo Tree star

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