Interleukin-34 Synovial Fluid Was Associated with Knee Osteoarthritis Severity: A Cross-Sectional Study in Knee Osteoarthritis Patients in Different Radiographic Stages.

Disease Markers
Shuang-Lei WangZhan-Chun Li

Abstract

Inflammation might play a crucial role in the pathogenesis of osteoarthritis (OA). Interleukin-34 (IL-34) is a well-known proinflammatory cytokine. The objective of this study was to detect IL-34 levels in serum and synovial fluid (SF) of patients with OA and to investigate their correlation with radiographic and symptomatic severity. One hundred and eighty-two OA patients and 69 controls were recruited. IL-34 levels were measured by enzyme-linked immunosorbent assay (ELISA). Radiographic and symptomatic severity of OA was reflected by Kellgren-Lawrence (KL) grades and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores, respectively. SF IL-34 levels were independently associated with the KL grade (B = 0.273, 95% CI: 0.150-0.395; P < 0.001). SF IL-34 levels were significantly correlated with WOMAC scores (r = 0.265, 95% CI: 0.123-0.399; P < 0.001). The correlation between SF IL-34 levels and WOMAC scores was still significant after adjusting for confounding factors (B = 0.020, 95% CI: 0.001-0.038; P = 0.035) in OA patients. We found that IL-34 levels in SF were significantly associated with the radiographic and symptomatic severity of knee OA.

References

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Citations

Jan 16, 2020·The Journal of Experimental Medicine·Iva LeliosMelanie Greter
Oct 23, 2020·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Zhe XuChuan Ye
Feb 9, 2021·Cartilage·Wanvisa UdomsinprasertSittisak Honsawek
Jan 23, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jakub MlostKatarzyna Starowicz
Sep 28, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Qian ZhangJiong Jiong Guo

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
X-ray

Software Mentioned

SPSS

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