Abstract
Neuroinflammation contributes to neuronal deficits in neurodegenerative CNS (central nervous system) autoimmune diseases, such as multiple sclerosis and uveitis. The major goal of most treatment modalities for CNS autoimmune diseases is to limit inflammatory responses in the CNS; immune-suppressive drugs are the therapy of choice. However, lifelong immunosuppression increases the occurrence of infections, nephrotoxicity, malignancies, cataractogenesis, and glaucoma, which can greatly impair quality of life for the patient. Biologics that target pathogenic T cells is an alternative approach that is gaining wide acceptance as indicated by the popularity of a variety of Food and Drug Administration (FDA)-approved anti-inflammatory compounds and humanized antibodies such as Zenapax, Etanercept, Remicade, anti-ICAM, rapamycin, or tacrolimus. B cells are also potential therapeutic targets because they provide costimulatory signals that activate pathogenic T cells and secrete cytokines that promote autoimmune pathology. B cells also produce autoreactive antibodies implicated in several organ-specific and systemic autoimmune diseases including lupus erythematosus, Graves' disease, and Hashimoto's thyroiditis. On the other hand, recent ...Continue Reading
Citations
Oct 1, 2015·International Immunology·Thomas F Tedder
Jan 31, 2017·Journal of Clinical Medicine·Jason S Ellis, Helen Braley-Mullen
Jan 10, 2018·Immunology·Hilary A SeifertHalina Offner
Apr 27, 2016·Journal of Neuroscience Research·Jinming HanTao Jin
Apr 9, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jinming HanTao Jin
May 10, 2018·Frontiers in Immunology·Katharina HofmannRudolf Armin Manz
Apr 3, 2019·Frontiers in Immunology·Kripa GuramAndrew B Sharabi
Apr 11, 2019·Nature Reviews. Rheumatology·Samuel J S RubinWilliam H Robinson
Sep 30, 2017·Nature Communications·Ivy M DambuzaCharles E Egwuagu
Sep 22, 2015·Frontiers in Pharmacology·Hong LeiHans-Dieter Volk
Oct 21, 2017·Frontiers in Immunology·Jin Kyeong ChoiCharles E Egwuagu
Jan 13, 2019·Oncogene·Shipra Das, Dafna Bar-Sagi
Nov 12, 2018·Auto- Immunity Highlights·Georgios K VasileiadisGeorgios M Hadjigeorgiou
Oct 26, 2018·Frontiers in Immunology·Igal Gery, Rachel R Caspi
Oct 9, 2019·Seminars in Immunopathology·Gerhild Wildner, Maria Diedrichs-Möhring
Aug 23, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Héloïse AuclairChantal Jayat-Vignoles
Jul 1, 2020·Shock·Monowar AzizPing Wang
Dec 22, 2020·Immunological Reviews·Siyuan MaMübeccel Akdis
Aug 28, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gerwyn MorrisMichael Maes
Mar 13, 2021·Scientific Reports·Maha Fahad AlenazyRabih Halwani
Feb 6, 2021·Allergy·Kirstin JansenWillem van de Veen
Apr 30, 2021·Frontiers in Immunology·YaYun LiuXueSong Liang
Aug 28, 2021·Cells·Mohamed KhalilSubramaniam Malarkannan