Interleukin 38 Protects Against Lethal Sepsis

The Journal of Infectious Diseases
Fang XuJu Cao

Abstract

Interleukin 38 (IL-38) is the most recently characterized cytokine of the interleukin 1 family. However, its role in sepsis remains unknown. Circulating IL-38 levels were measured in 2 cohorts of adult and pediatric patients with sepsis. Using 2 murine models of lipopolysaccharide (LPS)-induced endotoxemia and cecal ligation and puncture (CLP)-induced sepsis, the effects of IL-38 on survival, inflammation, tissue injury, and bacterial clearance were assessed. Serum IL-38 concentrations were significantly elevated in adult and pediatric patients with sepsis relative to corresponding healthy adult and pediatric controls, respectively. An increased IL-38 level negatively correlated with the number of blood leukocytes and with the level of inflammatory cytokines, including interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in clinical sepsis. Anti-IL-38 antibody impaired survival and while recombinant IL-38 improved survival in the 2 murine models of LPS-induced endotoxemia and CLP-induced sepsis. IL-38 administration decreased the inflammatory response, as reflected by lower levels of cytokines and chemokines (including IL-6, TNF-α, interleukin 10, interleukin 17, interleukin 27, CXCL1, and CCL2), and less damage to tissues ...Continue Reading

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Citations

Aug 30, 2019·Critical Care : the Official Journal of the Critical Care Forum·Hongmei TuJu Cao
Oct 22, 2019·Critical Care Medicine·Xingxing YanJu Cao
Dec 28, 2019·Journal of Cellular and Molecular Medicine·Yun GeYong-Ming Yao
Mar 17, 2020·EMBO Molecular Medicine·Jean-Marc CavaillonTomasz Skirecki
Oct 28, 2019·Cellular & Molecular Immunology·Xiaoyu SunChun-Kwok Wong
Sep 14, 2019·Nature Reviews. Rheumatology·Charles Anthony Dinarello
Jun 25, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Zhiwei XuMingcai Li
Feb 24, 2021·Journal of Leukocyte Biology·Dennis M de GraafRob J W Arts
Mar 17, 2021·International Immunopharmacology·Hua-Song XiaYan-Qing Wu
Oct 24, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rao MeFu-Shin X Yu

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