Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets

Journal of Cellular Physiology
G D SempowskiR P Phipps

Abstract

Pulmonary fibrosis is a potentially fatal consequence of treatments for malignancy and is an increasing problem in bone marrow transplant patients and in cases of allogenic lung transplant. The fibrotic response is characterized by increases in lung fibroblast number and collagen synthesis. This laboratory previously isolated stable, functionally distinct, murine lung fibroblast subsets (Thy-1+ and Thy-1-) to study the contribution of fibroblast subpopulations in lung fibrosis. The fibroblast fibrotic response may be induced by cytokines secreted by infiltrating cells such as T lymphocytes and mast cells. In the current study two key regulatory cytokines, interferon-gamma (IFN-gamma) and interleukin-4 (IL-4), were investigated for their effects on the collagen synthesis of murine lung fibroblast subsets. IL-4 and IFN-gamma are putatively characterized as fibrogenic and anti-fibrogenic cytokines, respectively, and are found in repairing lung tissue. Stimulation with recombinant IL-4 induced a100% increase in total collagen production only by Thy-1+ fibroblasts. Types I and III collagen mRNA were increased in the Thy-1+ fibroblasts, unlike the Thy-1- subset. In contrast, IFN-gamma decreased constitutive collagen production by mor...Continue Reading

References

Oct 1, 1992·The Journal of Clinical Investigation·A E PostlethwaiteR Raghow
Aug 1, 1991·The American Journal of Physiology·R H Goldstein
Jun 13, 1991·Biochimica Et Biophysica Acta·M MetsärantaE Vuorio
Mar 1, 1987·Gene Analysis Techniques·C B Harley
Feb 1, 1989·Current Opinion in Cell Biology·E Mandelkow, E M Mandelkow
Jul 1, 1989·American Journal of Respiratory Cell and Molecular Biology·R P PhippsM E Felch
Sep 1, 1989·American Journal of Respiratory Cell and Molecular Biology·S L Adams
Jun 1, 1986·Thorax·G J Laurent
Nov 1, 1988·Clinical Immunology and Immunopathology·J G MonroeP Lammie
Jan 1, 1986·Experimental Lung Research·K M Reiser, J A Last
Jan 1, 1986·Experimental Lung Research·R H Goldstein, A Fine
Dec 1, 1981·European Journal of Clinical Investigation·G J LaurentP Cockerill
Jan 1, 1983·International Review of Connective Tissue Research·J G ClarkR P Mecham
Oct 1, 1994·Pathology, Research and Practice·M J Arthur
Sep 1, 1994·Clinical Immunology and Immunopathology·K M FriesR P Phipps
Nov 1, 1994·American Journal of Respiratory Cell and Molecular Biology·K M FriesR P Phipps
Jan 1, 1995·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·A KucukcelebiM C Robson
Apr 1, 1995·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·G D SempowskiR P Phipps

❮ Previous
Next ❯

Citations

Aug 17, 2000·Springer Seminars in Immunopathology·C FonsecaC M Black
Dec 7, 2000·The American Journal of Pathology·S C WhitmanA Daugherty
Apr 24, 2001·International Journal of Radiation Oncology, Biology, Physics·P GottlöberR U Peter
Aug 7, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Stewart C WhitmanAlan Daugherty
Jun 19, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Goran SantakDubravko Forcić
Jul 13, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ruhangiz T KilaniEdward E Tredget
Dec 14, 2005·Postgraduate Medical Journal·S G Baidya, Q-T Zeng
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·S KononovB Suki
Oct 20, 2007·American Journal of Respiratory and Critical Care Medicine·Lourdes BarreraMoisés Selman
Aug 27, 2011·American Journal of Respiratory and Critical Care Medicine·Sandra Lo ReFrançois Huaux
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·G S DavisD R Hemenway
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·L M TeranJ M Schröder
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·T NagahoriK Yamamoto
Apr 18, 2001·American Journal of Respiratory Cell and Molecular Biology·M ArrasD Lison
Apr 18, 2001·American Journal of Respiratory Cell and Molecular Biology·G W Hoyle, A R Brody
Feb 21, 2004·American Journal of Respiratory Cell and Molecular Biology·Virginie BarbarinFrançois Huaux
Apr 20, 1999·The Journal of Clinical Investigation·J M SpergelR S Geha
Mar 20, 2010·Respiratory Research·Norihiro KikuchiNobuyuki Hizawa
Oct 11, 2005·Respiratory Research·Virginie BarbarinFrancois Huaux
Nov 17, 2005·Respiratory Research·Karina A Keogh, Andrew H Limper
Oct 27, 2004·BMC Infectious Diseases·Roberto Suárez-MéndezPedro A López-Saura
Feb 16, 2013·F1000 Biology Reports·Sergei P AtamasAchsah D Keegan
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z ShiD C Rockey
Oct 28, 2005·The American Journal of Pathology·Ji Hyung KimDoo Hyun Chung
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A N Aggarwal, D Behera
Sep 15, 2005·The Annals of Pharmacotherapy·Michael A Pacanowski, Guy W Amsden
Aug 10, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stefan G MattyasovszkyAlexander Hofmann
Jul 4, 2006·The American Journal of Pathology·Toru KimuraKiyohisa Sekizawa
Dec 10, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Véronique WinnepenninckxJoost J van den Oord

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory Cell and Molecular Biology
Francois HuauxDominique Lison
International Reviews of Immunology
V V Yurovsky, B White
© 2021 Meta ULC. All rights reserved