PMID: 8596674Oct 1, 1995Paper

Interleukin 4 (IL-4) and IL-6-producing memory T-cells in peripheral blood and gingival tissue in periodontitis patients with high serum antibody titers to Porphyromonas gingivalis

Oral Microbiology and Immunology
T AoyagiK Hara

Abstract

We assessed cytokine production and proliferation of memory T-cells that were isolated from peripheral blood of adult periodontitis patients with high anti-Porphyromonas gingivalis titer. Memory T-cells were stimulated with P. gingivalis lipopolysaccharide, sonicates and formalin-killed whole cells. Interleukin 4(IL-4)- and IL-6-producing cells were stained by immunocytochemistry on peripheral blood smears and compared with cryostat sections of autologous gingival biopsies. Memory T-cells in the peripheral blood of patients rated significantly higher than in healthy subjects (32.3 + or - 7.1 vs 25.3 + or - 3.0%). Stimulation of patient-derived memory T-cells with P. gingivalis whole cells induced higher IL-4 production than in healthy subjects (4.4 + or - 4.1% vs 0.7 + or - 0.6%). Induction of IL-4 producing memory T-cells by P. gingivalis lipopolysaccharide and whole cells was respectively 1.37 and 1.56 times that induced by medium alone. IL-6 production did not differ between the groups. Proliferation of memory T-cells in healthy subjects tended to be more inhibited by P. gingivalis antigens than that in patients. In some patients, induction of IL-4- and IL-6-producing memory T-cells in peripheral blood and in autologous ging...Continue Reading

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Citations

Nov 9, 2011·Clinical Oral Investigations·J R GonzalesJörg Meyle
Dec 18, 2002·Oral Microbiology and Immunology·E GemmellG J Seymour
Feb 24, 2001·Clinical and Experimental Immunology·D F LappinD F Kinane
Jul 15, 2005·Annals of Periodontology·Denis F Kinane, David F Lappin
Nov 6, 2002·Journal of Periodontology·Wihaskoro SosrosenoGregory J Seymour
Aug 15, 2001·Acta Odontologica Scandinavica·G J Seymour, E Gemmell
Aug 15, 2001·Acta Odontologica Scandinavica·D F Kinane, D F Lappin
Apr 27, 2004·Periodontology 2000·Erica Gemmell, Gregory J Seymour
Jan 12, 2007·Periodontology 2000·Kazuyuki Noguchi, Isao Ishikawa
Jan 12, 2007·Periodontology 2000·Denis F Kinane, P Mark Bartold
Jan 12, 2007·Periodontology 2000·Erica GemmellGregory J Seymour
Sep 14, 2007·Periodontology 2000·Yael Houri-HaddadLior Shapira
Apr 25, 2007·Journal of Clinical Periodontology·J R GonzalesJ Meyle
Jul 27, 2010·Journal of Clinical Periodontology·Gaudy L Torres de HeensUbele van der Velden
Jul 10, 2013·Journal of Periodontal & Implant Science·Anders M Lindroth, Yoon Jung Park
Sep 5, 2002·FEMS Immunology and Medical Microbiology·Pamela J BakerDerry C Roopenian
Jul 17, 2001·Periodontology 2000·D F KinaneJ Ebersole
Jul 5, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·E GemmellG J Seymour
Jul 5, 2002·Journal of Dental Research·E GemmellG J Seymour
Nov 12, 2014·The American Journal of Tropical Medicine and Hygiene·Kaitlin A O'KeefeFrank J Sorvillo
Nov 2, 2020·Journal of Clinical Periodontology·Nidhi MedaraNeil M O'Brien-Simpson
Mar 11, 2021·Periodontology 2000·Jessica D Hathaway-Schrader, Chad M Novince
Oct 15, 2020·Journal of Clinical Periodontology·Nidhi MedaraIvan B Darby
Aug 12, 1999·Biochemical and Biophysical Research Communications·A BanbulaJ Potempa

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