Interleukin 4 inhibits the interleukin 2-induced production of its functional antagonist, interferon gamma

Immunology Letters
F WagnerH Dancygier

Abstract

Interferon gamma (IFN gamma) inhibits many effects of interleukin (IL)-4. Its production largely parallels cell proliferation but is regulated independently. As IL-4 inhibits several IL-2-induced effects including proliferation of human peripheral blood mononuclear cells, we investigated its influence on the IL-2-induced IFN gamma production. We found that both absolute IFN gamma production and IFN gamma production per proliferation unit (1000 cpm) in response to IL-2 were inhibited by IL-4. IL-2-induced interferon production was inhibited by IL-4 in both sheep red blood cell rosetting and non-rosetting cells. In bidirectional mixed lymphocyte culture, IL-4 alone enhanced proliferation but suppressed IFN gamma production. As 48% of IFN gamma-producing cells are known to show T cell phenotype, the nearly total inhibition of IFN gamma production is evidence for suppression of T cell response to IL-2. Additionally, we found that the inhibition of IL-2-induced proliferation by IL-4 was significantly more pronounced at low cell densities. Basal proliferation was only inhibited in serum-containing media. These data stress the importance of other lymphokines or accessory cells in the regulation of early lymphocyte activation.

References

Jun 1, 1987·Immunological Reviews·S SandvigU Andersson

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Citations

Nov 1, 1991·The Journal of Experimental Medicine·F D FinkelmanW C Gause
Jun 23, 1993·Annals of the New York Academy of Sciences·C Bogdan, C Nathan
Oct 17, 2015·Nature Reviews. Drug Discovery·Namita A GandhiGeorge D Yancopoulos
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robin StephensDavid D Chaplin

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