PMID: 11919547Mar 29, 2002Paper

Interleukin-4 inhibits tumor necrosis factor-alpha-induced and spontaneous apoptosis of biomaterial-adherent macrophages

The Journal of Laboratory and Clinical Medicine
William G BrodbeckJames M Anderson

Abstract

Biocompatibility of implanted materials is determined by the host foreign-body response, which is comprised of cellular (adherent monocytes and macrophages) and soluble (secreted cytokines) components. Modulating the presence, activity or both of adherent macrophages may increase or decrease the biocompatibility of implants because these cells remain adherent to the implant surface and fuse to form foreign-body giant cells (FBGCs), leading to failure of the implant. An attractive mechanism of eliminating these cells is through the induction of apoptosis; therefore ways of inducing or inhibiting apoptosis of biomaterial-adherent inflammatory cells are being investigated. We hypothesized that interleukin-4 (IL-4) promotes macrophage survival by inhibiting tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. We found that TNF-alpha induces apoptosis in a time- and dose-dependent manner, whereas IL-4 inhibits TNF-alpha-induced and spontaneous apoptosis of biomaterial-adherent macrophages. Blocking experiments and evaluation of shedding of soluble TNF receptor type I (TNF-RI) demonstrated that endogenous TNF-alpha production is responsible for spontaneous apoptosis of biomaterial-adherent cells and that IL-4 inhibits this apop...Continue Reading

References

Jul 1, 1992·Journal of Biomedical Materials Research·M A CardonaS S Kaplan
Jul 1, 1992·Annals of Hematology·R MunkerW Wilmanns
Nov 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J W Larrick, S C Wright
May 1, 1990·Journal of Biomedical Materials Research·Q ZhaoP Urbanski
Jan 1, 1989·Annual Review of Immunology·B Beutler, A Cerami
Sep 1, 1988·The American Review of Respiratory Disease·Y MartinetR G Crystal
Feb 1, 1988·The Journal of Experimental Medicine·A McInnes, D M Rennick
Jun 1, 1986·The Journal of Experimental Medicine·C A DinarelloJ V O'Connor
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J B WeinbergM A Misukonis
Jul 1, 1982·The Journal of Pathology·A R MurchJ M Papadimitriou
Jan 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·C FadyA Lichtenstein
Aug 26, 1993·Nature·J OgasawaraS Nagata
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·A K McNally, J M Anderson
Jun 1, 1993·International Immunology·Y TakedaF Sendo
Oct 1, 1995·Journal of Biomedical Materials Research·W J KaoJ M Anderson
Jun 14, 1996·Cell·A Fraser, G Evan
Apr 29, 1998·Annual Review of Physiology·V J Kidd
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·L P Perera, T A Waldmann
Dec 22, 1999·Journal of Biomedical Materials Research·C R Jenney, J M Anderson
Dec 23, 1999·Current Opinion in Hematology·J M Anderson
Apr 5, 2001·Journal of Biomedical Materials Research·W G BrodbeckJ M Anderson

❮ Previous
Next ❯

Citations

Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
Aug 19, 2007·Journal of Internal Medicine·Kjell Larsson
May 9, 2009·Journal of Biomedical Materials Research. Part a·Sucharita P ShankarJulia E Babensee
Jul 25, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Philip J MarascalcoMarina V Kameneva
Aug 20, 2018·Bulletin of Experimental Biology and Medicine·D A Il'in, V A Shkurupy
Aug 11, 2010·Tissue Engineering. Part a·Gregory TourIon Tcacencu
Jan 29, 2011·Seminars in Immunopathology·James M Anderson, Amy K McNally
Nov 26, 2010·Journal of Biomedical Materials Research. Part a·Peng Meng Kou, Julia E Babensee
Jul 18, 2009·Journal of Biomedical Materials Research. Part a·Babak ChehroudiDonald Maxwell Brunette
Apr 24, 2008·Journal of Biomedical Materials Research. Part a·Analiz RodriguezJames M Anderson
Jan 18, 2008·Journal of Biomedical Materials Research. Part a·David T ChangJames M Anderson
Mar 30, 2016·Bulletin of Experimental Biology and Medicine·D A Il'inV A Shkurupy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Journal of Biomedical Materials Research
William G BrodbeckJ M Anderson
Proceedings of the National Academy of Sciences of the United States of America
William G BrodbeckJames M Anderson
Journal of Biomedical Materials Research. Part a
Anand Khandwekar, Cho K Rho
© 2022 Meta ULC. All rights reserved