Interleukin-4 plays a dominant role in Th1- or Th2-like responses during the primary immune response to the hapten penicillin

Molecular Immunology
S KerdineM Pallardy

Abstract

Despite a large number of studies on the Thl/Th2 balance during immune response to pathogens or protein antigens, little is known concerning the early events which regulate Thl/Th2 differentiation following a single injection of haptenic compounds. In this work, we studied how two mouse strains with different MHC haplotypes, SJL (H-2s) and Balb/c (H-2d), could develop different primary immune responses to subcutaneously injected benzylpenicillin coupled to tetanus toxoid (BPO-TT). The SJL mice showed a high BPO-specific IgG1 response that was maximum on day 10 and no BPO-specific IgG2a response. In contrast, Balb/c mice showed a high BPO-specific IgG2a response on days 15 and 22 and a weak IgG1 production. In SJL mice, the response to BPO-TT was characterized by a very early and high IL-4 mRNA expression. In Balb/c, a delayed and weaker expression of IL-4 mRNA was observed. Kinetics of IL-2 and IFN-gamma mRNA expression were comparable in both strains, but IFN-gamma mRNA expression was higher in SJL than in Balb/c. In vivo neutralization of IL-4 induced a significant BPO-specific IgG2a production and a two-fold reduction of IgG1 production in SJL mice while it accelerated production of BPO-specific IgG2a in Balb/c mice. In addi...Continue Reading

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Citations

Feb 13, 2001·Toxicology·H LebrecM Pallardy
Feb 18, 1999·Toxicology Letters·M PallardyH Lebrec
Jul 22, 2005·International Journal of Clinical Practice·H-L QiaoZ-M Dong
Apr 5, 1997·Annals of the New York Academy of Sciences·M J WalportM Botto
Jun 10, 2008·The Journal of Allergy and Clinical Immunology·Andrea J ApterTimothy Rebbeck
Jan 6, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D J NaisbittB K Park

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