Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths

The Journal of Experimental Medicine
V S PellyM S Wilson

Abstract

Immunity to intestinal helminth infections requires the rapid activation of T helper 2 cells (Th2 cells). However, simultaneous expansion of CD4+Foxp3+ regulatory T cells (T reg cells) impedes protective responses, resulting in chronic infections. The ratio between T reg and effector T cells can therefore determine the outcome of infection. The redifferentiation of T reg cells into Th cells has been identified in hyperinflammatory diseases. In this study, we asked whether ex-T reg Th2 cells develop and contribute to type-2 immunity. Using multigene reporter and fate-reporter systems, we demonstrate that a significant proportion of Th2 cells derive from Foxp3+ cells after Heligmosomoides polygyrus infection and airway allergy. Ex-Foxp3 Th2 cells exhibit characteristic Th2 effector functions and provide immunity to H. polygyrus Through selective deletion of Il4ra on Foxp3+ cells, we further demonstrate IL-4 is required for the development of ex-Foxp3 Th2 cells. Collectively, our findings indicate that converting T reg cells into Th2 cells could concomitantly enhance Th2 cells and limit T reg cell-mediated suppression.

References

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J F UrbanF D Finkelman
Aug 11, 1994·Nucleic Acids Research·S J ClarkM Frommer
Apr 18, 1996·Nature·K TakedaS Akira
Apr 17, 2002·The Journal of Experimental Medicine·Jyothi RengarajanLaurie H Glimcher
Nov 9, 2002·Bioinformatics·Long-Cheng Li, Rajvir Dahiya
Dec 13, 2006·European Journal of Immunology·Jun WangRené E M Toes
Feb 15, 2007·PLoS Biology·Stefan FloessJochen Huehn
Mar 24, 2007·Nature Reviews. Immunology·Daniel J Campbell, Steven F Ziegler
Jun 15, 2007·European Journal of Immunology·Constance A M FinneyRick M Maizels
Oct 20, 2007·Nature Reviews. Immunology·Yasmine Belkaid
Nov 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jun WeiF Xiao-Feng Qin
Mar 5, 2008·Infection and Immunity·Sebastian RauschSusanne Hartmann
May 20, 2008·Nucleic Acids Research·Yuichi KumakiMasaki Okano
Jan 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Noriko KomatsuShohei Hori
Mar 3, 2009·Immunity·Wojciech WojciechowskiFrances E Lund
Mar 18, 2009·European Journal of Immunology·João H DuarteJocelyne Demengeot
Dec 10, 2009·The Journal of Experimental Medicine·De'Broski R HerbertFred D Finkelman
Dec 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Georgia Perona-WrightMarkus Mohrs
Jun 1, 2010·Immunity·Siamon Gordon, Fernando O Martinez
Sep 30, 2010·The Journal of Experimental Medicine·John R GraingerRick M Maizels
Oct 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lauren KastnerF Xiao-Feng Qin
Oct 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yunqi WangYisong Y Wan
Jan 27, 2011·Nature Reviews. Immunology·Daniel J Campbell, Meghan A Koch
Oct 4, 2011·The Journal of Clinical Investigation·Elizabeth A WohlfertYasmine Belkaid
Jan 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leo HansmannMatthias Edinger
Apr 27, 2012·European Journal of Immunology·Michelle M CollazoWilliam G Kerr
Oct 12, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deepali V SawantAlexander L Dent
Jun 4, 2013·Nature·Rahul RoychoudhuriNicholas P Restifo
Jul 6, 2013·Nature Reviews. Immunology·William C GauseJudith E Allen
Oct 19, 2013·The Journal of Clinical Investigation·Hyung-seung JinYun-Cai Liu
Dec 24, 2013·Nature Medicine·Noriko KomatsuHiroshi Takayanagi

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Citations

Aug 23, 2017·PLoS Neglected Tropical Diseases·Justin Komguep NonoFrank Brombacher
Oct 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yue LiM Nedim Ince
Dec 6, 2018·Journal of Cellular and Molecular Medicine·Verena Moosbrugger-MartinzSandrine Dubrac
Jan 30, 2018·F1000Research·Azza Abdel-GadirTalal A Chatila
Oct 31, 2017·Nature Reviews. Immunology·Jennifer A Walker, Andrew N J McKenzie
Sep 11, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Hani Harb, Talal A Chatila
Nov 11, 2018·Nature Communications·Sung-Min HwangSin-Hyeog Im
Apr 9, 2019·The Journal of Clinical Investigation·Ting WenMarc E Rothenberg
Oct 15, 2019·Frontiers in Immunology·Zhongmei Zhang, Xuyu Zhou
Mar 12, 2020·Non-coding RNA·Riccardo GuidiMark S Wilson
Mar 7, 2020·Microbiology and Molecular Biology Reviews : MMBR·Matteo BelloneSamuel Huber
Nov 23, 2017·Frontiers in Immunology·Cornelia Symowski, David Voehringer
Dec 15, 2020·The Journal of Allergy and Clinical Immunology·Jee H LeeYun-Cai Liu
Apr 27, 2021·Frontiers in Immunology·Xundong WeiXuyu Zhou
Mar 2, 2021·Frontiers in Immunology·Terhi RuohtulaUNKNOWN DIABIMMUNE Study Group
May 12, 2021·European Journal of Immunology·Vikas SaxenaJonathan S Bromberg

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Methods Mentioned

BETA
PCR
FACS
Flow
PMA
flow cytometry
ABTS
Protein Assay
Assay
immunoprecipitation

Software Mentioned

GraphPad
MethPrimer
GeneSpring
Seqbuilder Quantification Tool for Methylation Analysis ( QUMA
Prism
MicroArray Suite
Excel
Ingenuity Pathways Analysis

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