Interleukin-4 protects from chemotherapy-induced peripheral neuropathy in mice modal via the stimulation of IL-4/STAT6 signaling

Acta Cirúrgica Brasileira
Qingbin ShiFeng Wang

Abstract

To investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. The mouse model of vincristine-induced peripheral neuropathy and interleukin (IL)-4 knockout mice were utilized to investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Vincristine induced increased sensitivity to mechanical stimulation was measured by von Frey hair test 7 and 14 days after intraperitoneal administration of 0.1 mg/kg vincristine in mice. Relative expression levels of cytokines were detected by quantitative real-time PCR. STAT6 expression following vincristine treatment was assessed with western blotting. We discovered that IL-4/STAT6 signaling was down-regulated in vincristine-treated mice. Deletion of IL-4 in mice increased the sensitivity to mechanical allodynia. IL-4 knockout mice also produced more pro-inflammatory cytokines, including IL-1β and TNF-α. Notably, co-administration of exogenous recombination IL-4 significantly prevented vincristine-induced mechanical allodynia. Anti-inflammatory cytokine IL-4 protects rodent model from vincristine-induced peripheral neuropathy via the stimulation of IL-4/STAT6 signaling and inhibition of the pro-inflammatory c...Continue Reading

References

Nov 1, 1986·Medical Toxicology·S S Legha
Feb 1, 1970·Journal of the Neurological Sciences·W G BradleyJ N Walton
Mar 2, 1999·British Journal of Pharmacology·F Q CunhaS H Ferreira
Apr 17, 2002·Journal of Neurology·Stefan Quasthoff, Hans Peter Hartung
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Mariana L ValeRonaldo A Ribeiro
Nov 26, 2003·The Journal of Experimental Medicine·Kotaro SuzukiItsuo Iwamoto
Mar 10, 2005·Experimental Neurology·Stephen B McMahonFabien Marchand
Oct 30, 2007·Archives of Physical Medicine and Rehabilitation·Andrew L DaviesGregory A Dekaban
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Dec 20, 2008·Nature Reviews. Neuroscience·Erin D Milligan, Linda R Watkins
Nov 26, 2009·Indian Journal of Pediatrics·Sunil GomberDevender Chhonker
Oct 5, 2010·Nature Reviews. Drug Discovery·Charles Dumontet, Mary Ann Jordan
Feb 15, 2011·Pediatric Blood & Cancer·Doralina L AnghelescuChing-Hon Pui
Sep 13, 2011·Critical Reviews in Oncology/hematology·Andreas A ArgyriouGuido Cavaletti
Aug 7, 2014·Korean journal of anesthesiology·Hue Jung Park
Dec 3, 2014·Neuroscience Letters·V A CarozziA Chiorazzi
Jan 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca McKelveyMaria Fitzgerald
Jun 20, 2015·Pain Management·Jessica A Boyette-DavisPatrick M Dougherty
Nov 1, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karen KrukowskiAnnemieke Kavelaars

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