PMID: 7544011Aug 15, 1995Paper

Interleukin 4 signals through two related pathways

Proceedings of the National Academy of Sciences of the United States of America
A PernisP Rothman

Abstract

The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS). It is not known whether the IL-4-mediated activation of these substrates occurs via related or distinct signaling pathways. We report that 32D cells, an IL-3-dependent myeloid progenitor cell line in which no phosphorylated 4PS is found, activate high levels of STF-IL4 in response to IL-4. Consistent with the known requirement for 4PS or insulin receptor substrate 1 (IRS-1) in IL-4-mediated mitogenesis, activation of STF-IL4 in 32D cells is not sufficient for IL-4-inducible c-myc expression. In addition, we have examined the ability of 32D cells transfected with different truncation mutants of the human IL-4 receptor to activate Jak-3 kinase and STF-IL4 in response to human IL-4. As in the case of 4PS/IRS-1, we have found that activation of both Jak-3 and STF-IL4 requires the presence of the IL-4 receptor region comprising aa 437-557. The finding that the same region of the IL-4 receptor is required for the induction of both 4PS/IRS-1 and STF-IL4 suggests that the IL-4-stimulated activation of these two substrates migh...Continue Reading

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Citations

Feb 24, 2006·Archives of Pharmacal Research·Yong Woo Lee, Anjali A Hirani
Oct 13, 1998·The Journal of Allergy and Clinical Immunology·R L MillerP Rothman
Jan 13, 2000·Current Opinion in Immunology·P Y Pan, P Rothman
May 23, 1998·The Journal of Experimental Medicine·H Huang, W E Paul
Oct 18, 2000·The Journal of Experimental Medicine·J ZhuW E Paul
Sep 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Nilesh R MaitiS Jaharul Haque
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·J LosmanP Rothman
Oct 4, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mei-Lun WangGary D Wu
May 4, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tohru HosoyamaCharles Keller
Apr 28, 2011·Neurosurgery·Yan Michael Li, Walter A Hall
Nov 10, 2011·Toxins·Yan Michael Li, Walter A Hall
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S MiyataM Sugita
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·B K PatelW J LaRochelle
May 23, 2013·Pharmacology & Therapeutics·Tareq A JuratliDietmar Krex
Nov 19, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Danielle Karo-AtarAriel Munitz
Jun 26, 2002·Neoplasia : an International Journal for Oncology Research·Jennifer L GoochDouglas Yee
Oct 7, 2004·Trends in Molecular Medicine·Talal A Chatila
Feb 3, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Christine McDonaldNancy C Reich
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Jul 9, 2002·Molecular and Cellular Biology·Glenn M Manthey, Adam M Bailis
Nov 29, 2002·Microbiology and Molecular Biology Reviews : MMBR·Lorraine S Symington

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