PMID: 2504304Sep 1, 1989Paper

Interleukin-4 stimulates human monocytes to produce tissue-type plasminogen activator.

Blood
P H HartJ A Hamilton

Abstract

Tissue-type plasminogen activator (t-PA) is involved in the lysis of blood clots (fibrinolysis) and is used clinically for this purpose. Endothelial cells are one source of the t-PA present in blood. We report here that interleukin-4 (IL-4) (0.1 to 0.25 U/mL; 1 to 3 x 10(-11) mol/L), but not interferon-gamma (IFN-gamma), elevates t-PA messenger (m)RNA expression and secretion of t-PA activity by human monocytes, with the maximum response at 2.5 U/mL. Supernatant t-PA activity was detected within three hours of exposure to IL-4 and maximum activity within six hours. Thus, IL-4 may control fibrin deposition at sites of inflammation during cell-mediated immune responses, as well as having a therapeutic role in thrombolysis.

Citations

Dec 1, 1992·Toxicology Letters·J B CornacoffJ H Dean
Jan 1, 1991·Progress in Growth Factor Research·D W MaherG Morstyn
Jan 13, 2000·Clinics in Dermatology·A Claudy
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·S T SmileyM J Grusby
Aug 1, 1993·Journal of the American Academy of Dermatology·S J MahlerD R Pulitzer
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Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·Mirella ProfitaAntonio M Vignola

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