PMID: 7541141Jun 20, 1995Paper

Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells

Proceedings of the National Academy of Sciences of the United States of America
Makoto MurakamiJ P Arm

Abstract

Mouse bone marrow-derived mast cells (BMMCs) developed with interleukin 3 (IL-3) can be stimulated by c-kit ligand (KL) and accessory cytokines over a period of hours for direct delayed prostaglandin (PG) generation or over a period of days to prime for augmented IgE-dependent PG and leukotriene (LT) production, as previously reported. We now report that IL-4 is counterregulatory for each of these distinct KL-dependent responses. BMMCs cultured for 4 days with KL + IL-3 or with KL + IL-10 produced 5- to 7-fold more PGD2 and approximately 2-fold more LTC4 in response to IgE-dependent activation than BMMCs maintained in IL-3 alone. IL-4 inhibited the priming for increased IgE-dependent PGD2 and LTC4 production to the level obtained by activation of BMMCs maintained in IL-3 alone with an IC50 of approximately 0.2 ng/ml. IL-4 inhibited the KL-induced increase in expression of cytosolic phospholipase A2 (cPLA2) but had no effect on the incremental expression of PG endoperoxide synthase 1 (PGHS-1) and hematopoietic PGD2 synthase or on the continued baseline expression of 5-lipoxygenase, 5-lipoxygenase activating protein, and LTC4 synthase. BMMCs stimulated by KL + IL-10 for 10 h exhibited a delayed phase of PGD2 generation, which was...Continue Reading

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Citations

Feb 16, 1999·Biochimica Et Biophysica Acta·Y Urade, O Hayaishi
Dec 1, 1996·Current Opinion in Immunology·M A Beaven, R A Baumgartner
Jan 1, 1996·Mediators of Inflammation·Y S Bakhle, R M Botting
Sep 3, 2013·Chemical & Pharmaceutical Bulletin·Gui-Hua QuanYoung-Won Chin
Sep 18, 1999·Archives of Pharmacal Research·H H KimY Jahng
May 6, 2006·The Journal of Allergy and Clinical Immunology·Maryse ThiviergeMarek Rola-Pleszczynski
Jun 14, 2005·Molecular Immunology·Yuichiro OhtsukaTakeshi Tokuhisa
Dec 1, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Seiko NarushimaDaniel J Berg
Apr 9, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M ThurnherL Höltl
Jan 5, 2001·British Journal of Pharmacology·D H WrightK M Metters
Jun 18, 2017·Biological Chemistry·Julia Esser-von Bieren
May 9, 1997·The Journal of Biological Chemistry·D C SwinneyC S Ramesha
May 27, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Masafumi ZaitsuEiichi Ishii
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ann E Kelly-WelchAchsah D Keegan
Sep 27, 2008·Journal of Reproductive Immunology·C AnderleP Sedlmayr

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