Interleukin 5 and interleukin 3 induce serine and tyrosine phosphorylations of several cellular proteins in an interleukin 5-dependent cell line

Biochemical and Biophysical Research Communications
Y MurataK Takatsu

Abstract

Murine interleukin 5 (IL-5), a lymphokine produced by helper T cells, is involved in the regulation of growth and differentiation of B cells and eosinophils. To elucidate the intracellular events via the IL-5 receptor, we have investigated IL-5-induced protein phosphorylation in an IL-5-dependent murine early B-lineage cell line (T88-M). The rapid phosphorylation of a 60-kDa protein at serine residues and of 140-, 92-, 53-, 48-, and 45-kDa proteins at tyrosine residues were induced by the stimulation of T88-M cells with IL-5. T88-M cells were found to proliferate in response to IL-3 as well as IL-5, and the phosphoproteins in T88-M cells could be induced by IL-3 stimulation in a similar manner of those induced by IL-5. Thus, these results suggest that the protein phosphorylation events in T88-M cells may be shared by both pathways via the IL-5 receptor and the IL-3 receptor.

References

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Citations

Aug 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A TominagaK Takatsu
May 1, 1992·International Journal of Cell Cloning·A Miyajima
Dec 10, 2002·International Immunopharmacology·Tatsuaki MorokataToshimitsu Yamada
Jan 1, 1991·Microbiology and Immunology·K Takatsu
Aug 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T van der Bruggen, L Koenderman
Jan 1, 1994·Trends in Endocrinology and Metabolism : TEM·T KitamuraA Miyajima
Feb 4, 1998·The Journal of Allergy and Clinical Immunology·T van der BruggenL Koenderman
Jan 1, 1993·Cancer Investigation·S Mahanty, T B Nutman
Jan 10, 2002·Brain, Behavior, and Immunity·M J SchwarzM Ackenheil
May 4, 1992·Annals of the New York Academy of Sciences·K TakatsuA Tominaga
Nov 1, 1992·Clinical and Experimental Immunology·B M FoxwellM Feldmann

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