PMID: 8551223Jan 1, 1996

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

The Journal of Experimental Medicine
P S FosterI G Young


Airways inflammation is thought to play a central role in the pathogenesis of asthma. However, the precise role that individual inflammatory cells and mediators play in the development of airways hyperreactivity and the morphological changes of the lung during allergic pulmonary inflammation is unknown. In this investigation we have used a mouse model of allergic pulmonary inflammation and interleukin (IL) 5-deficient mice to establish the essential role of this cytokine and eosinophils in the initiation of aeroallergen-induced lung damage and the development of airways hyperreactivity. Sensitization and aerosol challenge of mice with ovalbumin results in airways eosinophilia and extensive lung damage analogous to that seen in asthma. Aeroallergen-challenged mice also display airways hyperreactivity to beta-methacholine. In IL-5-deficient mice, the eosinophilia, lung damage, and airways hyperreactivity normally resulting from aeroallergen challenge were abolished. Reconstitution of IL-5 production with recombinant vaccinia viruses engineered to express this factor completely restored aeroallergen-induced eosinophilia and airways dysfunction. These results indicate that IL-5 and eosinophils are central mediators in the pathogene...Continue Reading


Oct 1, 1998·European Journal of Immunology·A J CoyleM Kopf
Jul 6, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Brombacher
Apr 12, 2001·European Journal of Immunology·L ZabeauJ Tavernier
Oct 2, 2002·Journal of Applied Toxicology : JAT·Rebecca J DearmanIan Kimber
Feb 10, 2000·Springer Seminars in Immunopathology·T Biedermann, M Röcken
Dec 7, 2006·Archives of Pharmacal Research·Hyun-Mo YangSang-Hun Jung
May 10, 2001·International Journal of Hematology·C J BagleyA F Lopez
Sep 21, 2007·Archives of Pharmacal Research·Hyun-Mo YangSang-Hun Jung
Feb 16, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Qing WangJianying Zhou
Mar 17, 2007·Cellular and Molecular Life Sciences : CMLS·S G Trivedi, C M Lloyd
Jan 30, 2008·Archives of Environmental Contamination and Toxicology·Takamichi IchinoseTakayuki Shibamoto
Oct 12, 2005·Journal of Human Genetics·Hyun Sub CheongHyoung Doo Shin
Dec 31, 2009·Cellular and Molecular Neurobiology·Sung-Hwa SohnHyunsu Bae
Oct 7, 2010·Inflammation·Linh Kan BuiYoichiro Horii
May 12, 2011·Journal of Clinical Immunology·Rituparna DasRichard Bucala
Jan 25, 2003·Current Allergy and Asthma Reports·Mi-Na Kweon, Hiroshi Kiyono
Aug 10, 2012·Current Allergy and Asthma Reports·Zhaleh J Amini-VaughanDavid P Huston
Aug 2, 2013·Current Allergy and Asthma Reports·Rachid Berair, Ian D Pavord
Mar 17, 2004·Biochimica Et Biophysica Acta·W S Fred Wong, Khai Pang Leong
Apr 28, 2004·Cytokine & Growth Factor Reviews·Jun YangDeborah F Talkington
Apr 22, 2004·International Immunopharmacology·Arpita Bharadwaj, Devendra K Agrawal
Sep 17, 2013·Trends in Immunology·Julie DeckersHamida Hammad
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Ming YangPaul S Foster
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Margarita Martinez-Moczygemba, David P Huston
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Marc E Rothenberg
May 24, 2005·Pharmacology & Therapeutics·James D Moffatt
Nov 26, 2003·Respiratory Physiology & Neurobiology·Rachel A CollinsR K Kumar
Feb 14, 2004·Methods : a Companion to Methods in Enzymology·Udo HerzUrsula Wiedermann
Oct 17, 2002·Respiratory Physiology & Neurobiology·Ching-Chi LinChing-Yuang Lin
Mar 12, 2003·Toxicology and Applied Pharmacology·Takamichi IchinoseTakayuki Shibamoto
Jan 11, 2001·Pharmacology & Therapeutics·L Cohn, A Ray
Jul 13, 2002·Pharmacology & Therapeutics·Y Riffo-Vasquez, D Spina
Jul 13, 2002·Pharmacology & Therapeutics·Paul S FosterDavid B Corry
Aug 7, 2002·Pharmacology & Therapeutics·Adrian J BaatjesJudah A Denburg
Jan 1, 1997·Pharmacology & Therapeutics·S P Hogan, P S Foster
Feb 12, 1998·Trends in Pharmacological Sciences·C G PerssonF Sundler
Nov 7, 1998·Biochimica Et Biophysica Acta·J E Valentine, W A Sewell


Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Oct 1, 1991·The Journal of Allergy and Clinical Immunology·D H BroideS I Wasserman
May 1, 1991·The Journal of Clinical Investigation·Q HamidP K Jeffery
Dec 1, 1990·The American Review of Respiratory Disease·M AzzawiA B Kay
Feb 1, 1990·The American Review of Respiratory Disease·Y Sibille, H Y Reynolds
Jan 1, 1988·The Journal of Experimental Medicine·A F LopezM A Vadas
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
May 1, 1988·The Journal of Allergy and Clinical Immunology·G J GleichP M Vanhoutte
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H D CampbellI G Young
Dec 1, 1993·The American Review of Respiratory Disease·P J MauserW Kreutner
Feb 1, 1994·The Journal of Experimental Medicine·C A DahindenM Baggiolini
Jan 1, 1994·Annual Review of Immunology·B S BochnerL M Lichtenstein
Jan 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G G BrusselleH Bluethmann
Feb 1, 1994·Current Opinion in Immunology·P F Weller
Dec 1, 1993·European Journal of Immunology·A J Ramsay, M Kohonen-Corish
Feb 1, 1994·The Journal of Experimental Medicine·S DubucquoiM Capron
Jan 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T IwamaA Koda
Apr 1, 1993·American Journal of Respiratory Cell and Molecular Biology·M B Resnick, P F Weller

Related Concepts

Respiratory Tract Structure
Lung Diseases
Bronchoalveolar Lavage Fluid
Bronchoconstrictor Effect
Aerosol Dose Form

Related Feeds


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.