PMID: 9182686Jun 16, 1997Paper

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

The Journal of Experimental Medicine
J J LeeN A Lee

Abstract

We have generated transgenic mice that constitutively express murine interleukin (IL)-5 in the lung epithelium. Airway expression of this cytokine resulted in a dramatic accumulation of peribronchial eosinophils and striking pathologic changes including the expansion of bronchus-associated lymphoid tissue (BALT), goblet cell hyperplasia, epithelial hypertrophy, and focal collagen deposition. These changes were also accompanied by eosinophil infiltration of the airway lumen. In addition, transgenic animals displayed airway hyperresponsiveness to methacholine in the absence of aerosolized antigen challenge. These findings demonstrate that lung-specific IL-5 expression can induce pathologic changes characteristic of asthma and may provide useful models to evaluate the efficacy of potential respiratory disease therapies or pharmaceuticals.

References

Aug 1, 1992·The American Review of Respiratory Disease·H NakajimaS Yoshida
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B P Hackett, J D Gitlin
Sep 11, 1992·Respiratory Medicine·C KroegelH Matthys
Oct 11, 1990·The New England Journal of Medicine·J BousquetP Godard
Nov 1, 1990·The Journal of Experimental Medicine·L A DentC J Sanderson
Aug 1, 1990·American Journal of Respiratory Cell and Molecular Biology·R Pabst, I Gehrke
Jan 1, 1988·The Journal of Allergy and Clinical Immunology·P M O'Byrne
Jan 1, 1985·International Archives of Allergy and Applied Immunology·J Bienenstock
Dec 1, 1993·The American Review of Respiratory Disease·P J MauserW Kreutner
Jan 1, 1994·Drugs·N Chanarin, S L Johnston
Jan 1, 1995·International Archives of Allergy and Immunology·T Iwamoto, K Takatsu
Oct 1, 1995·The Journal of Experimental Medicine·P D CollinsT J Williams
May 1, 1995·European Journal of Immunology·K J ErbA Elbe
Mar 1, 1995·The Journal of Experimental Medicine·A J CoyleG Le Gros
Mar 1, 1995·American Journal of Respiratory Cell and Molecular Biology·G BrusselleR Pauwels
Nov 1, 1994·Journal of Leukocyte Biology·V P KurupR L Coffman
Jun 1, 1994·American Journal of Respiratory Cell and Molecular Biology·S H GavettM Wills-Karp
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·D E McBrideW R Henderson
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LewisR M Perlmutter
Jan 1, 1996·The Journal of Experimental Medicine·J M DrazenK F Austen
Apr 1, 1996·American Journal of Respiratory Cell and Molecular Biology·N KrugP H Howarth
Mar 1, 1996·The Journal of Allergy and Clinical Immunology·J LefortB B Vargaftig
May 1, 1996·American Journal of Respiratory Cell and Molecular Biology·D I BlythD Fattah
May 1, 1996·The Journal of Allergy and Clinical Immunology·J VengeP Venge
Jun 1, 1996·The Journal of Allergy and Clinical Immunology·S SurL W Hunt
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·J A RankinR A Flavell
Sep 19, 1996·Nature·S E DanielsW O Cookson
Oct 1, 1996·The Journal of Experimental Medicine·D R BrownS L Reiner
Nov 1, 1996·The Journal of Experimental Medicine·E A SabinE J Pearce
Mar 1, 1997·American Journal of Respiratory and Critical Care Medicine·E HamelmannE W Gelfand

❮ Previous
Next ❯

Citations

Nov 10, 1998·European Journal of Immunology·A BraunH Renz
Oct 27, 2009·Inflammatory Bowel Diseases·Eoin N McNameeJesçs Rivera-Nieves
Feb 10, 2000·Springer Seminars in Immunopathology·T Biedermann, M Röcken
Dec 7, 2006·Archives of Pharmacal Research·Hyun-Mo YangSang-Hun Jung
Feb 1, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shuhan YanXuming Deng
Mar 17, 2007·Cellular and Molecular Life Sciences : CMLS·S G Trivedi, C M Lloyd
Oct 7, 2010·Inflammation·Linh Kan BuiYoichiro Horii
May 12, 2011·Journal of Clinical Immunology·Rituparna DasRichard Bucala
Jul 30, 2011·Transgenic Research·Alfred DoyleJames J Lee
Jan 25, 2003·Current Allergy and Asthma Reports·Heidi Isenberg-FeigAndrea Keane-Myers
May 17, 2007·Current Allergy and Asthma Reports·Elizabeth A JacobsenJames J Lee
Apr 24, 2007·Current Allergy and Asthma Reports·Clare M Lloyd
Aug 10, 2012·Current Allergy and Asthma Reports·Zhaleh J Amini-VaughanDavid P Huston
Dec 23, 2008·Archives of Pharmacal Research·Ok-Kyoung KwonHyeong-Kyu Lee
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Minqi HaoAndre Nel
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Margarita Martinez-Moczygemba, David P Huston
Feb 14, 2004·Methods : a Companion to Methods in Enzymology·Udo HerzUrsula Wiedermann
Jan 11, 2001·Pharmacology & Therapeutics·L Cohn, A Ray
Jul 13, 2002·Pharmacology & Therapeutics·Y Riffo-Vasquez, D Spina
Jul 13, 2002·Pharmacology & Therapeutics·Paul S FosterDavid B Corry
Oct 26, 1999·Immunology Today·J C Gutierrez-RamosJ A Gonzalo
May 28, 2003·European Journal of Medicinal Chemistry·Sang-Hun JungYoungsoo Kim
Aug 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·K P Leong, D P Huston
Aug 15, 2000·The International Journal of Biochemistry & Cell Biology·Y Riffo-VasquezD Spina
Oct 18, 2003·Cytokine & Growth Factor Reviews·Elizabeth L LynchWilliam W Cruikshank
Jun 18, 2003·Current Opinion in Pharmacology·Darryl AdamkoRedwan Moqbel
Nov 30, 2002·Paediatric Respiratory Reviews·Lindsay Baldwin, William R Roche
Aug 5, 2000·Allergy·Y Riffo-VasquezD Spina
Jan 11, 2011·Nature Immunology·Van Trung ChuClaudia Berek
Sep 6, 2005·Nature Immunology·Baohua ZhouSteven F Ziegler
Nov 3, 1998·Immunology and Cell Biology·S P HoganP S Foster
Feb 13, 2001·Pathology International·K SanoK Matsumoto
Aug 24, 2005·Medical Mycology·T MadanP U Sarma
Dec 6, 2000·The Journal of Experimental Medicine·Z WangJ A Elias
Mar 5, 2008·The Journal of Experimental Medicine·Elizabeth A JacobsenJames J Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.