Interleukin-5 mRNA expressed by eosinophils and gamma/delta T cells in parasite-immune sheep

European Journal of Immunology
S BaoA J Husband

Abstract

Interleukin (IL)-5 is produced by variety of cell types and contributes to both lymphocyte development an eosinophil terminal differentiation in vitro. The coincidence of worm expulsion and eosinophilia in sheep infected with the gastrointestinal nematode Trichostrongylus colubriformis suggest that eosinophils may be involved as effector cells in host immunity against parasite infection. The role of IL-5 in this process was investigated by observing the distribution of IL-5 mRNA+ cells in the small intestine, mesenteric lymph nodes (MLN) and Peyer's patches (PP) by an in situ hybridization technique using a murine IL-5 riboprobe. IL-5 mRNA+ cells were distributed throughout the lamina propria (LP) of the small intestine from the tips of the villi to the muscularis mucosae and in the parafollicular areas of MLN and PP in both naive and immune sheep. The phenotypes of IL-5 mRNA+ cells was explored by simultaneous eosin and immunohistochemical staining using a monoclonal antibody recognizing the T19 marker, which identifies a major subset of gamma/delta TCR+ cells in sheep. In immune sheep, there was about a five-fold increase in the number of eosinophils and IL-5 cell mRNA+ cells in the LP, but there was no significant change in ...Continue Reading

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Citations

Aug 1, 1996·Veterinary Parasitology·D L Emery
Dec 11, 2003·Parasitology International·Tuan BendixsenDavid L Emery
Aug 1, 1996·International Journal for Parasitology·A J HusbandA J Ramsay
Sep 29, 1999·International Journal for Parasitology·D L EmeryT Bendixsen
Sep 6, 2000·Veterinary Immunology and Immunopathology·J ShenA J Husband
Jun 20, 2002·Veterinary Immunology and Immunopathology·Alan J Husband
Dec 30, 1999·Veterinary Immunology and Immunopathology·A J HusbandK W Beagley
Jun 6, 2000·Advanced Drug Delivery Reviews·J W Simecka
Dec 1, 1996·Immunology and Cell Biology·M RiffkinP Wood
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Jun 28, 2017·Heliyon·Emmanuelle Moreau, François Meurens
Aug 24, 1999·Immunology and Cell Biology·K BoswardT Bendixsen
Jul 15, 2020·Biophysics Reviews·Shisan Bob Bao
Aug 24, 1999·Infection and Immunity·Y Zhang, E Y Denkers

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