Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice

American Journal of Respiratory and Critical Care Medicine
S P HoganP S Foster

Abstract

Although activated CD4+ T cells have been implicated in the pathogenesis of asthma, the direct contribution of this leukocyte to the induction of aeroallergen-induced bronchial hyperreactivity and lung damage is unknown. In the present investigation, we have used a model of allergic airways inflammation, which displays certain phenotypic characteristics of late-phase asthmatic responses, together with interleukin-5-deficient (IL-5-/- ) mice and donor antigen-specific CD4+ TH2-type cells to obtain unequivocal evidence for a role of this T lymphocyte in the pathophysiology of allergic airways inflammation. Antigen-primed CD4+ T cells and CD4- cells (CD4+-depleted population) were purified from the spleens of ovalbumin (OVA)-sensitized wild-type mice and adoptively transferred to OVA-sensitized and nonsensitized IL-5-/- mice. In vitro stimulation of the purified cell populations with OVA resulted in the secretion of IL-4 and IL-5, but not interferon-gamma, from the CD4+ T cells, indicating that they were of the TH2 type. In contrast, interferon-gamma, but not IL-4 and IL-5, was produced by the CD4- T cells. The CD4+ TH2-type cells (but not the CD4 cells) reconstituted aeroallergen (OVA)-induced blood and airways eosinophilia, lung...Continue Reading

References

Mar 15, 1992·The Biochemical Journal·J Stanková, M Rola-Pleszczynski
Aug 1, 1992·The American Review of Respiratory Disease·H NakajimaS Yoshida
Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Nov 1, 1991·The American Review of Respiratory Disease·S P O'HickeyT H Lee
Dec 1, 1991·The Journal of Allergy and Clinical Immunology·J V BossoD D Stevenson
May 1, 1991·The Journal of Clinical Investigation·Q HamidP K Jeffery
Aug 1, 1990·The Journal of Allergy and Clinical Immunology·P J ManningP M O'Byrne
Aug 1, 1990·The American Review of Respiratory Disease·R DjukanovićS T Holgate
Dec 1, 1990·The American Review of Respiratory Disease·M AzzawiA B Kay
Sep 1, 1981·Journal of Cellular Physiology·R I Sha'afiE J Goetzl
Oct 1, 1981·The Journal of Experimental Medicine·R A LewisE J Corey
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P F WellerR A Lewis
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R L HooverR A Lewis
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J M DrazenE J Corey
Oct 1, 1982·The Journal of Clinical Investigation·D W MacGlashanL M Lichtenstein
Dec 1, 1993·The American Review of Respiratory Disease·P J MauserW Kreutner
Sep 1, 1995·The Journal of Clinical Investigation·A WatanabeJ G Martin
Jun 1, 1995·American Journal of Respiratory Cell and Molecular Biology·J D KennedyI M Richards
Jun 1, 1995·The Journal of Clinical Investigation·M KanekoH Kita
Mar 1, 1995·The Journal of Experimental Medicine·M E RothenbergP Leder
Jan 1, 1994·Annual Review of Immunology·B S BochnerL M Lichtenstein
Jan 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G G BrusselleH Bluethmann
Jan 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T IwamaA Koda
Oct 1, 1996·The Journal of Experimental Medicine·J A MacLeanA D Luster

❮ Previous
Next ❯

Citations

Jan 24, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·W XiongJ Fu
Mar 15, 2002·Current Allergy and Asthma Reports·Darryl AdamkoRedwan Moqbel
Feb 11, 2004·Current Allergy and Asthma Reports·Darryl AdamkoRedwan Moqbel
Mar 17, 2004·Biochimica Et Biophysica Acta·W S Fred Wong, Khai Pang Leong
Jul 13, 2002·Pharmacology & Therapeutics·Y Riffo-Vasquez, D Spina
Aug 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·K P Leong, D P Huston
Aug 15, 2000·The International Journal of Biochemistry & Cell Biology·Y Riffo-VasquezD Spina
Apr 3, 2002·Trends in Molecular Medicine·Paul S FosterDianne C Webb
Nov 24, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M BensonO Strannegård
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K G TournoyR A Pauwels
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R K KumarP S Foster
Nov 3, 1998·Immunology and Cell Biology·S P HoganP S Foster
Mar 27, 2001·Immunology and Cell Biology·R K Kumar, P S Foster
May 17, 2000·Current Opinion in Pulmonary Medicine·M F Lipscomb, J A Wilder
Mar 23, 2006·Annual Review of Immunology·Leo Lefrançois, Lynn Puddington
Mar 23, 2006·Annual Review of Immunology·Marc E Rothenberg, Simon P Hogan
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·J C KipsR A Pauwels
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Makoto YoshidaMark D Inman
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Yasushi Fujitani, Alexandre Trifilieff
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Gang ChengTakeshi Fukuda
Nov 6, 2001·American Journal of Respiratory Cell and Molecular Biology·M YangP S Foster
Feb 21, 2003·American Journal of Respiratory Cell and Molecular Biology·Frédéric F LittleWilliam W Cruikshank
Apr 17, 2004·American Journal of Respiratory Cell and Molecular Biology·Nina E KingMarc E Rothenberg
Feb 26, 2005·American Journal of Respiratory Cell and Molecular Biology·Nives ZimmermannMarc E Rothenberg
Jun 11, 2005·American Journal of Respiratory Cell and Molecular Biology·Stefan HammerschmidtHubert Wirtz
Dec 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Seok-Yong EumJames G Martin
Sep 3, 2002·American Journal of Respiratory Cell and Molecular Biology·Rakesh K Kumar, Paul S Foster
Jun 16, 2000·Journal of Immunological Methods·H M DavisD E Griswold
May 15, 2002·Trends in Pharmacological Sciences·Paolo Montuschi, Peter J Barnes
Nov 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Iwona StelmachJoanna Jerzynska
Oct 16, 2003·Nitric Oxide : Biology and Chemistry·Sarit OfferZecharia Madar
Nov 25, 2003·Prostaglandins & Other Lipid Mediators·Ramin Farzaneh-Far, Kevin Moore
Sep 5, 2002·British Journal of Pharmacology·Stephen L UnderwoodMaria G Belvisi
Sep 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anthony JoethamErwin W Gelfand
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·S P HoganM E Rothenberg
Nov 2, 1999·The Journal of Experimental Medicine·L CohnK Bottomly
Jan 16, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Siiri AltrajaAlan Altraja
Mar 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hee Sun ParkYong Chul Lee
Dec 9, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Taylor A DohertyMichael Croft
Oct 24, 2013·BioMed Research International·Nathália Brandão GobbatoEdna Aparecida Leick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.