Interleukin-5 receptors on human lung eosinophils after segmental allergen challenge

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Peter JuliusJ Christian Virchow

Abstract

IL-5 is a specific cytokine for eosinophil accumulation, activation and prolongation of survival and can be recovered in elevated concentrations from the bronchoalveolar compartment in atopic asthma following allergen challenge. The action of IL-5 is mediated via the specific IL-5 receptor-alpha (IL-5Ralpha). Although in vitro data suggest that IL-5R expression is regulated by cytokines such as IL-3, IL-5 and GM-CSF, IL-5R regulation in vivo and its kinetics following allergen provocation are incompletely understood. We investigated IL-5R regulation in vivo following segmental allergen provocation (SAP) with an individually standardized dose of allergen in 12 patients with atopic asthma. Lavage was performed 10 min and 18 h (eight patients) and 10 min and 42 h (eight patients) after allergen challenge. In addition to differential cell counts, IL-5Ralpha was measured by flow cytometry and IL-5 concentrations in bronchoalveolar lavage (BAL) fluid were determined by ELISA. IL-5Ralpha expression decreased significantly on peripheral blood and on BAL eosinophils 18 and 42 h after SAP. In contrast, IL-5 concentrations increased significantly in BAL fluid 18 and 42 h after SAP. In four and two patients, respectively, there were detect...Continue Reading

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Citations

Sep 11, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yijun TangChunling Du
Sep 18, 2007·American Journal of Respiratory and Critical Care Medicine·Patrick Flood-PageUNKNOWN International Mepolizumab Study Group
Nov 22, 2007·The Journal of Allergy and Clinical Immunology·Peter JuliusJohann Christian Virchow
Jun 1, 2018·Journal of Leukocyte Biology·Patricia C Fulkerson
Apr 17, 2008·The Journal of Nervous and Mental Disease·Ulrich W Ebner-PriemerMartin Bohus
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mandy E BurnhamLoren C Denlinger
Feb 18, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Manal A IbrahimRasha N Mohammed

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