Interleukin 6-174 G/C promoter gene polymorphism in centenarians: no evidence of association with human longevity or interaction with apolipoprotein E alleles

Experimental Gerontology
Cristiano CapursoFrancesco Panza

Abstract

The C allele at position -174 in the promoter of the interleukin 6 (IL-6) gene has been associated with reduced gene expression and reduced plasma levels of IL-6. Given that IL-6 tracks with functional disability and age-related diseases, there may be attrition or reduction in the frequency of the homozygous subjects, who produce higher IL-6 serum levels, in older survivors in a population. In fact, a marked reduction of the IL-6*G/*G genotype was recently demonstrated in male though not female Italian centenarians compared with younger age groups. First aim of the present study was to investigate whether there was evidence of an association among IL-6 -174 G/C promoter polymorphism and extreme longevity in a population of 81 centenarians compared with a control group of 122 middle-aged healthy subjects (mean age: 51+/-18 SD; range: 19-73 years), from Apulia (Southern Italy). Secondly, we also tested possible interaction of apolipoprotein E (APOE) alleles with the IL-6 -174 G/C promoter polymorphism in view of our recent findings for reduced APOE epsilon4 allele in centenarians. No differences have been found in the IL-6 -174 G/C promoter allele and genotype frequencies between centenarians and controls nor was there any observ...Continue Reading

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Citations

Jan 27, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M Daniele Fallin, Amy Matteini
Jun 15, 2011·Annals of Human Genetics·Digna R Velez EdwardsWilliam K Scott
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Jun 14, 2017·Scientific Reports·Guodong LiuChunling Tan
Jan 14, 2020··Huang JianBirga Anteneh Mengesha

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