Interleukin-6 affects scopolamine-induced amnesia, but not brain amino acid levels in mice

Neuroreport
Mauro BianchiAlberto E Panerai

Abstract

We have previously shown that, after peripheral administration, different cytokines affect cognitive functions in mice. In this study, we evaluated the effects of mouse interleukin-6 (IL-6) on the classical behavioural test of scopolamine-induced amnesia for a passive avoidance response in the mouse. Pretraining i.p. administration of this cytokine (0.125 and 0.5 microgram/mouse) significantly reduced the amnesic action of the muscarinic receptor antagonist. As it is well known that brain amino acids are deeply involved in the modulation of cognitive processes we measured the levels of glutamine, aspartic acid, glutamic acid and GABA in the hippocampus and hypothalamus of mice treated with IL-6. At both doses which affected the cognitive functions, this cytokine had no effect on brain levels of measured amino acids. Neither nociceptive thresholds to a thermal stimulus, nor spontaneous locomotor activity were modified by the acute administration of IL-6 (0.5 microgram/mouse). Our data confirm previous observations indicating that peripheral administration of cytokines affects some, but not other brain functions and suggest the involvement of IL-6 in the central modifications induced by the immune activation.

References

Oct 31, 1994·Annals of the New York Academy of Sciences·L G Miller, J M Fahey
Sep 26, 1994·Neuroscience Letters·W A BanksE G Gutierrez
Dec 1, 1993·Brain Research. Cognitive Brain Research·M Bianchi, A E Panerai
Apr 1, 1993·Brain Research. Cognitive Brain Research·M Bianchi, A E Panerai
Feb 1, 1996·Endocrine Reviews·H O Besedovsky, A del Rey

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Citations

Jul 22, 2004·Behavioural Brain Research·Daniela BraidaMariaelvina Sala
Apr 24, 1999·The European Journal of Neuroscience·M BianchiP Sacerdote
Dec 11, 2002·Journal of the American Geriatrics Society·Craig J WilsonHarvey J Cohen
Oct 9, 2007·European Journal of Pharmacology·Anna HryniewiczMaria M Winnicka

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