PMID: 9171222Jun 10, 1997Paper

Interleukin 6 and AIDS-associated Kaposi's sarcoma: a nested case control study within the Multicenter AIDS Cohort Study

AIDS Research and Human Retroviruses
I DouradoR Detels

Abstract

Since the beginning of the AIDS epidemic, there has been considerable research on the etiology of Kaposi's sarcoma (KS) among HIV-infected individuals. A number of studies have confirmed that HIV or HIV-encoded products can interact with human cells to induce the production of cytokines, including interleukin 6 (IL-6). In vitro observations have indicated that AIDS-KS cells can produce significant levels of IL-6 and also respond to this cytokine. Preliminary data suggested that IL-6 may be elevated among HIV-infected individuals that subsequently develop AIDS-KS. The objective of this study was to determine if elevated levels of IL-6 are associated with an increased incidence of AIDS-KS compared to other AIDS-defining illnesses such as opportunistic infections (OIs). Serum IL-6 levels were determined by ELISA in frozen sera collected from participants in the Multicenter AIDS Cohort Study (MACS) at 6 months prior to AIDS diagnosis, in 73 cases (AIDS-KS), and 152 controls (OI). Elevated IL-6 levels were more prevalent among men with AIDS-OI than those with AIDS-KS: crude odds ratio (OR), 0.4 (95% CI, 0.2-0.9). Models of multivariate logistic regression were used to study potential confounders. Sexual behavior variables did not se...Continue Reading

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Citations

Feb 9, 2002·AIDS·Steven A MilesUNKNOWN AIDS Malignancy Consortium
Oct 20, 2006·Journal of Virology·Melanie M BrinkmannThomas F Schulz
Jul 11, 2003·Hematology/oncology Clinics of North America·Susan E Krown
Sep 10, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·E C BreenO Martínez-Maza

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