Interleukin-6 and antiphospholipid antibodies in women with contraceptive-related thromboembolic disease

Obstetrics and Gynecology
Barbara Salobir, Miso Sabovic

Abstract

The aim of this study was to explore the possible (joint) contributing role of interleukin-6 (IL-6) and antiphospholipid antibodies to the occurrence of the venous thromboembolism in women using oral contraceptives. Interleukin-6 and antiphospholipid antibodies (anti-beta2-glycoprotein I antibody-immunoglobulin M [IgM], G [IgG], and A [IgA]; anticardiolipin-IgM and IgG; antiphosphatidylserine-IgM and IgG) were measured in 30 women (median age 41, range 28-49 years) in the stable period (on average 3.5 years) after first venous thromboembolism. Sixteen patients used oral contraceptives during the episode of venous thromboembolism (oral contraceptives group), whereas 14 patients did not (non-oral contraceptives group). Thirty-seven age-matched, healthy women served as controls Compared with controls, the oral contraceptives group had elevated IL-6 (median interquartile range 2.3 [1.1-4.3] versus 1.4 [0-2.0] pg/mL, P <.05). The oral contraceptives group had elevated anti-beta2-glycoprotein I antibody-IgM in comparison with both the non-oral contraceptives group (median interquartile range 47.5 [2.0-77.0] versus 29.50 [11.00-45.50] OD(450), P <.06) and controls (47.5 [2.0-77.0] versus 17.5 [3.5-30.0] OD(450), P <.001). Interleukin-...Continue Reading

References

Jan 1, 1992·Life Sciences·J WeiG P Hemmings
Mar 12, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·I MartinelliP M Mannucci
Apr 21, 1999·Lancet·F R Rosendaal
Apr 28, 1999·Lancet·M Greaves
Jan 13, 2000·Archives of Internal Medicine·K W BloemenkampJ P Vandenbroucke
Jun 1, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P Hannaford
Jun 23, 2000·Pflügers Archiv : European journal of physiology·T IharaT Bamba
Feb 24, 2001·Mediators of Inflammation·M AbramM Dorić
Mar 14, 2001·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·A L NightingaleR D Farmer
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·P A KernG Ranganathan
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Jean-Philippe BastardBernard Hainque
May 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M LaimerJ R Patsch
Jun 5, 2002·Neuroimmunomodulation·B D SalkeldJ G Cannon

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Citations

Mar 3, 2009·Nature Clinical Practice. Rheumatology·Doruk Erkan, Michael D Lockshin
Mar 29, 2005·Diabetes·Kathleen M GillespieEdwin A M Gale
Jan 12, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·N DayanV Tagalakis

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Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.