Interleukin-6 and interleukin-8 in newborn bacterial infection

American Journal of Perinatology
S S MehrP Henschke

Abstract

The objective of this study is to determine the plasma concentrations and diagnostic accuracy of interleukin-6 (IL-6) and interleukin-8 (IL-8) in newborn infection. One hundred and one newborn infants with clinical signs of infection during their primary hospitalization were investigated with the minimum of a blood culture, C-reactive protein (CRP), full blood examination (FBE), and cytokine concentrations (IL-6 and IL-8). Infection in infants was classified without knowledge of cytokine levels into four groups-definite (n = 11), probable (n = 12), uncertain (n = 52), and nil (n = 26). The median concentrations of IL-6 and IL-8 were significantly higher in the definitely infected group compared with the other three groups (p <0.05). At the cut-off concentration of highest accuracy, IL-6 (>175 pg/mL) and IL-8 (>28 pg/mL) had similar sensitivities (80 and 82%, respectively) and specificities (91 and 81%, respectively). Cut-off concentrations could be identified with improved sensitivities (90% for IL-6 and 100% for IL-8) that maintained specificity >50%. However, the confidence intervals were wide for all sensitivities and specificities. IL-6 and IL-8 had little diagnostic accuracy in infants with probable infection. IL-6 and IL-...Continue Reading

Citations

Oct 29, 2003·Cytokine·Akhil MaheshwariDarlene A Calhoun
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
May 25, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Marc LabenneJean-Bernard Gouyon
Aug 18, 2012·Journal of Paediatrics and Child Health·Alicia Rose JonesLex W Doyle
Feb 24, 2006·Pediatric Research·Malgorzata A Verboon-MaciolekGer T Rijkers
Mar 29, 2003·Journal of Perinatal Medicine·Blanca E GonzalezVineet Bhandari
Mar 14, 2003·Cytokine·Akhil MaheshwariDarlene A Calhoun
Mar 12, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Nazli ErcanAhmet Alim
Jan 15, 2019·The Cochrane Database of Systematic Reviews·Jennifer Valeska Elli BrownWilliam McGuire
Apr 19, 2005·Expert Review of Molecular Diagnostics·Dimitris A KafetzisChristos Costalos
May 7, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Reese ClarkDaniel K Benjamin
May 27, 2003·Clinical Chemistry·Attila TárnokRudi Varro

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