Interleukin-6 and interleukin-8 serum levels in prognosis of hormone-dependent breast cancer

Cytokine
J MilovanovicMarko Radulovic

Abstract

Increasing amount of evidence points to the importance of immunity in breast cancer. The prognostic value of cytokines and their effect on tumorigenesis remains inconsistent. To investigate the prognostic significance of IL6 and IL8 and their association with ER and HER2 in estrogen-dependent (ER+) breast cancer. The study included 79 premenopausal women with early and locally advanced ER+ breast cancer. All patients received adjuvant hormonal therapy: tamoxifen alone (56/79) or combination with LHRH agonist goserelin (23/79). IL6 and IL8 serum protein levels were measured by ELISA. Cox proportional hazards regression analysis was implemented for prognostic evaluation of the data categorized based on metastasis outcome. IL6 associated with good (P = 0.001, HR = 0.05) and IL8 with poor disease outcome (P = 0.03, HR = 2.5) in the whole group of patients. Multivariate analyses highlighted IL6 as the independent prognostic factor (P = 0.001, HR = 0.0007). When patients were classified according to ER or HER2 status, IL6 did not have prognostic significance in ERlow and ERhigh subgroups, while IL8 retained prognostic significance only in the ERhigh subgroup (P = 0.04, HR = 2.8). IL6 was significant in both HER2- (P = 0.001, HR = 0.0...Continue Reading

Citations

May 16, 2020·Oxidative Medicine and Cellular Longevity·Ana Paula C R FerrazCamila R Corrêa
Nov 11, 2019·Journal of Experimental & Clinical Cancer Research : CR·Yiwei WangQian Huang
Mar 28, 2020·Genetic Testing and Molecular Biomarkers·David JavaleraAdrian Daneri-Navarro
Oct 23, 2020·International Journal of Molecular Sciences·Adriana PapadimitropoulouRuth Lupu
Jul 26, 2021·Advances in Medical Sciences·Nataša Todorović-RakovićMarko Radulovic

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