PMID: 2504990Jul 17, 1989Paper

Interleukin-6 and its receptor during homeostasis, inflammation, and tumor growth

Klinische Wochenschrift
J Bauer

Abstract

This review focuses on describing the specific role of interleukin-6 within the network of inflammatory mediators in man. Sites of interleukin-6 synthesis, regulation of its expression, and the biological functions of this molecule are here outlined. The potential role of interleukin-6 as a diagnostic monitor is discussed. Particular attention is paid to experimental evidence that interleukin-6 and its receptor may be involved in the pathogenesis of autocrine tumor growth. A recently proposed therapeutical use of cytotoxic interleukin-6 fusion proteins in order to selectively, destroy certain interleukin-6 receptor bearing tumor cells is discussed in the light of the finding, that not only hepatocytes, but also normal peripheral blood monocytes express the interleukin-6 receptor.

References

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T HiranoT Kishimoto
Jun 27, 1986·Deutsche medizinische Wochenschrift·G RamadoriK H Meyer zum Büschenfelde
May 1, 1988·European Journal of Immunology·T GeigerP C Heinrich
Jul 15, 1988·European Journal of Biochemistry·T GeigerP C Heinrich
Nov 1, 1988·European Journal of Immunology·T HiranoM Feldmann
Jul 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B OjeniyiV T Rosdahl
Apr 29, 1989·Lancet·A O'Garra
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·T TagaT Kishimoto
Mar 31, 1989·Biochemical and Biophysical Research Communications·C SuzukiY Akiyama
May 1, 1989·The Journal of Clinical Investigation·G J FreemanL M Nadler
Oct 1, 1989·Archives of Biochemistry and Biophysics·U SanthanamL T May
Apr 1, 1988·The Journal of Experimental Medicine·P SeckingerJ M Dayer
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y H ZhangJ Vilcek
Oct 17, 1987·Lancet·M W NijstenL A Aarden
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J Van SnickR J Simpson
Nov 29, 1985·Science·B M WoloskiJ E Blalock
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P B SehgalF H Ruddle
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A RayP B Sehgal
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L ChenM Revel
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R C JambouD M Fowlkes
Dec 4, 1986·Nature·A Billiau
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P B SehgalI Tamm
Apr 1, 1988·European Journal of Immunology·F A HoussiauJ Van Snick
Feb 1, 1988·The Journal of Experimental Medicine·A MuraguchiT Kishimoto
May 16, 1988·Biochemical and Biophysical Research Communications·L T MayP B Sehgal
Jun 30, 1988·Biochemical and Biophysical Research Communications·K NoriokaH Nakamura
Jun 30, 1988·Biochemical and Biophysical Research Communications·M Turner, M Feldmann

❮ Previous
Next ❯

Citations

Dec 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·H MoriT Tamaya
Jan 1, 1996·Rheumatology International·T SentürkG Tokgöz
Jun 1, 1991·Annals of Hematology·J Bauer, F Herrmann
Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·M HüllJ Bauer
Jan 1, 1991·Biochimie·G H FeyW Northemann
Aug 15, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J J Pestka, H R Zhou
Apr 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R ScamurraM P Murtaugh
May 16, 2012·Journal of Pediatric Hematology/oncology·Victor M AquinoPatrick J Leavey
Sep 11, 1990·European Journal of Biochemistry·K Decker
Dec 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P De ManC Svanborg
Jan 26, 1999·Annals of the New York Academy of Sciences·J W van der MeerB J Kullberg
May 31, 2011·Journal of Minimally Invasive Gynecology·Luiz CarvalhoMauricio Simões Abrão
Jun 3, 2008·Molecular Immunology·Barbara CastellanaJosep V Planas
Jul 1, 1992·Research in Immunology·J BauerM Berger
Nov 1, 1991·Immunology Today·J BauerM Berger
May 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation·A LassonK Ohlsson
Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T AndusW Gerok
Jun 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J BauerG Acs
Aug 1, 1990·European Journal of Clinical Investigation·O SonneC Munck Petersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.