PMID: 16521477Mar 9, 2006Paper

Interleukin-6 attenuates the development of experimental diabetes-related neuropathy

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Emile AndriambelosonNoelle Callizot

Abstract

Neuropathy is the most severe and the least understood complication of diabetes. We investigated the potential neuroprotective effect of IL-6 therapy in an experimental model of diabetic neuropathy. A single i.v. injection of streptozotocin (STZ, 55 mg/kg) was used to induce experimental diabetes in adult males. IL-6 (1, 10 or 30 microg/kg) was administrated either intraperitoneally on a daily basis or subcutaneously (s.c.) on a daily, on a three times or one time per week basis, starting at day 10 post-STZ. A decrease in sensory nerve conduction velocity (SNCV), indicative of neuropathy, is seen in STZ rats as early as day 10 post-STZ, a time at which blood glycaemia is already maximal. At later time points, this electrophysiological impairment became severe and clinically apparent by affecting tail flick latency. Motor dysfunction defined by a significant increase in compound muscle action potential (CMAP) latency was also recorded. At the completion of the study (day 40 post-STZ), histological examination revealed significant axonopathy and myelin loss, along with an increase in the proportion of fibers with abnormal appearance in sciatic nerves of STZ rats. These changes were not observed in non-diabetic rats and were signi...Continue Reading

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Citations

Nov 26, 2010·Journal of Neurology·Ming-Ou Lu, Jie Zhu
Mar 10, 2009·Pakistan Journal of Biological Sciences : PJBS·H R SameniM Makvandi
Mar 11, 2010·COPD·Cağatay OncelFatma Evyapan
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Nov 17, 2020·Frontiers in Neurology·Baoyan FanXian Shuang Liu
Apr 25, 2021·Journal of Neuroimmunology·Kathleen M Hagen, Shalina S Ousman

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