Interleukin-6 concentrations in wound fluids rather than serological markers are useful in assessing bacterial triggers of ulcer inflammation.

International Wound Journal
Andreas AmbroschJŭrgen Preissler

Abstract

Bacterial pathogenicity, microbial load and diversity are decisive for outcome and therapy of non healing ulcers. However, until now, no routine laboratory parameter is available to assess the inflammatory level caused by chronic wound infections. We thus investigated the usefulness of levels of interleukin (IL)-6 and tumour necrosis factor alpha (TNFalpha) in wound fluids for assessing ulcer inflammation in the presence or absence of microbial triggers. In addition, the predictive values of local cytokine analyses were compared with those of C-reactive protein (CRP) and lipopolysaccharide-binding protein (LBP) because serological markers are normally used to underline the suspicion of wound infections. The present data from chronic arterial and venous ulcers (n = 45) clearly show that mixed bacterial infections increased IL-6 and TNFalpha concentrations in wound fluids when compared with ulcers with a monomicrobial infection (P < 0.01 and P < 0.05, respectively). IL-6 was also significantly elevated when a high bacterial load [versus <10(5) colony-forming units (cfu)/ml: P = 0.04] or an infection with Pseudomonas was observed (versus isolation of non Pseudomonas strains: P = 0.05). Although distinct proinflammatory triggers ma...Continue Reading

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Citations

Apr 9, 2011·Der Internist·R Lobmann
Feb 11, 2011·The Journal of Investigative Dermatology·Yen Chen LiuR Rivkah Isseroff
Dec 7, 2011·Experimental Dermatology·Mayumi AsadaHiromi Sanada
Dec 21, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Rachael L McInnesRyan Moseley
Jun 19, 2013·The International Journal of Lower Extremity Wounds·Markus W LöfflerStefan Beckert
Jun 19, 2013·The International Journal of Lower Extremity Wounds·Nikolaos Papanas, Raj Mani
Oct 5, 2010·Phlebology·Andrew W Bradbury
Mar 11, 2010·Journal of Wound Care·R D WolcottS E Dowd
Jul 30, 2019·Frontiers in Medicine·Karim SalehArtur Schmidtchen
Nov 4, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Cornelia WiegandGary W Gibbons

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