Interleukin-6 deficiency attenuates angiotensin II-induced cardiac pathogenesis with increased myocyte hypertrophy

Biochemical and Biophysical Research Communications
Fan ChenJunmei Ye

Abstract

Interleukin-6 (IL-6) signaling is critical for cardiomyocyte hypertrophy, while the role of IL-6 in the pathogenesis of myocardium hypertrophy remains controversial. To determine the essential role of IL-6 signaling for the cardiac development during AngII-induced hypertension, and to elucidate the mechanisms, wild-type (WT) and IL-6 knockout (IL-6 KO) mice were infused subcutaneously with either vehicle or AngII (1.5 μg/h/mouse) for 1 week. Immunohistological and serum studies revealed that the extents of cardiac fibrosis, inflammation and apoptosis were reduced in IL-6 KO heart during AngII-stimulation, while cardiac hypertrophy was obviously induced. To investigate the underlying mechanisms, by using myocardial tissue and neonatal cardiomyocytes, we observed that IL-6/STAT3 signaling was activated under the stimulation of AngII both in vivo and in vitro. Further investigation suggested that STAT3 activation enhances the inhibitory effect of EndoG on MEF2A and hampers cardiomyocyte hypertrophy. Our study is the first to show the important role of IL-6 in regulating cardiac pathogenesis via inflammation and apoptosis during AngII-induced hypertension. We also provide a novel link between IL-6/STAT3 and EndoG/MEF2A pathway that...Continue Reading

Citations

Feb 23, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Madhu V SinghFrançois M Abboud
Oct 31, 2020·Journal of Cellular and Molecular Medicine·Małgorzata GałdyszyńskaJacek Drobnik
Jul 8, 2019·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shu NieLiying Wang
Dec 17, 2020·Frontiers in Cardiovascular Medicine·Zheng XiaoHe Huang
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Xin LiuJunli Guo

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