Interleukin-6 (IL-6) and IGF-IGFBP system in children and adolescents with type 1 diabetes mellitus

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
A WedrychowiczA Wedrychowicz

Abstract

Some studies suggest that IL-6 is connected with glucose metabolism and insulin action, so like IGF-IGFBPs system it could play the role in diabetes etiopathogenesis. The aim of the study was therefore to test the hypothesis that in children and adolescents IL-6 is of importance for the etiopathogenesis of diabetes mellitus type 1 and that IL-6 is connected with carbohydrate metabolism and IGF-IGFBPs action. There were 49 patients with type 1 diabetes: 10 persons at onset diabetes and 39 with disease lasted at least 1 year and 33 age-matched healthy children included into the study. Serum IGF-I concentrations were measured by RIA; IGFBP-1 and IGFBP-2 by IRMA and IL-6 concentrations using quantitative ELISA immunoassays. HbA1c was measured by HPLC method. Multiple regression, ANOVA, and Student's t-test were used for statistical analysis. IL-6 and IGF-I, IGFBP-1 and IGFBP-2 levels did not differ statistically significant between diabetic patients and controls. IL-6 concentrations were statistically higher at onset diabetes than in diabetic patients with long-term disease. IL-6 did not correlate with IGF-I and its binding proteins - 1 and - 2 in examined groups. At onset of disease IL-6 correlated with insulin requirement. There ...Continue Reading

Citations

Jul 26, 2006·Mediators of Inflammation·Yasar DoganMetin Kaya Gurgoze
Apr 8, 2010·The Journal of Clinical Endocrinology and Metabolism·Janet K Snell-BergeonDana Dabelea
Oct 29, 2011·Endocrine Journal·Kyriaki KaravanakiChristina Karayianni
Mar 28, 2013·Mediators of Inflammation·Monika Ryba-StanisławowskaMałgorzata Myśliwiec
Mar 8, 2011·Cytokine & Growth Factor Reviews·Markus F Neurath, Susetta Finotto
May 8, 2018·Brain, Behavior, and Immunity·Juliana B DrummondAntonio L Teixeira

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