PMID: 9547164Apr 18, 1998Paper

Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients

Neuroscience Letters
P MärzU Otten

Abstract

We quantitated interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R) and soluble form of the IL-6 signal-transducing protein gp130 (sgp130) in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) (n = 17) and control subjects (n = 18) using sensitive enzyme-linked immunosorbent assays (ELISA). Our results show that none of the parameters examined was significantly different in CSF of AD patients as compared to control age-matched non-demented patients. We conclude that CSF levels of IL-6 and their soluble receptors do not necessarily reflect local changes of the IL-6 system that has been shown to be involved in neurodegenerative events occurring in AD. Levels of sgp130 are substantially high (approximately 100 ng/ml) in the CSF of all individuals probably representing a high antagonistic potential.

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Citations

Nov 27, 2004·European Archives of Psychiatry and Clinical Neuroscience·Harald HampelHans-Jürgen Möller
Sep 18, 2009·Journal of Neurology·Kurt A Jellinger
Jul 5, 2005·Journal of Psychiatric Research·Elke RichartzKlaus Schott
Jan 26, 1999·Cytokine & Growth Factor Reviews·E N Benveniste
Jun 10, 2000·European Journal of Biochemistry·S H HoischenS Rose-John
Oct 6, 1999·The European Journal of Neuroscience·P MärzS Rose-John
Dec 11, 2002·Journal of the American Geriatrics Society·Craig J WilsonHarvey J Cohen
Dec 12, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Olga BraunStefan Rose-John
Jun 27, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marcello MaggioLuigi Ferrucci
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·J J HoozemansP Eikelenboom
Aug 20, 2010·International Journal of Alzheimer's Disease·A AnoopSamir K Maji
Feb 26, 2014·Molecular Neurobiology·Frederic BrosseronMichael T Heneka
Feb 23, 2013·Mechanisms of Ageing and Development·Kimberly D JacobMichele K Evans
Oct 6, 2015·Alzheimer's Research & Therapy·Malin WennströmOskar Hansson
May 1, 2007·Expert Opinion on Therapeutic Targets·Stefan Rose-JohnDirk Seegert
Mar 27, 2016·Biochimica Et Biophysica Acta·Michelle RothaugStefan Rose-John
Apr 23, 2009·European Journal of Pharmacology·Ulrike MayJürgen Scheller
Jan 5, 2002·Annals of Neurology·K A JellingerI Wichart
Oct 19, 2017·Restorative Neurology and Neuroscience·Klaus Heese
Oct 16, 2007·Neuro-degenerative Diseases·Rita João GuerreiroCatarina Oliveira
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S A JonesG M Fuller
Apr 5, 2014·Journal of the American Geriatrics Society·Andrea L MettiJane A Cauley
May 2, 2014·Metabolic Brain Disease·Isabel Trapero, Omar Cauli
May 18, 2019·Current Alzheimer Research·Leonardo Guzman-MartinezLeonardo P Navarrete
May 16, 2002·Neurobiology of Aging·C E TeunissenC De Bruijn
Jan 10, 2002·Brain, Behavior, and Immunity·M J SchwarzM Ackenheil
Dec 11, 2007·Archives of Medical Research·Leonel E RojoRicardo B Maccioni
Nov 18, 2008·Neurobiology of Disease·Rebecca Craig-SchapiroDavid M Holtzman
Aug 10, 2010·Biological Psychiatry·Walter SwardfagerNathan Herrmann

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