Interleukin 6 in intact and injured mouse peripheral nerves

The European Journal of Neuroscience
Fanny ReichertShlomo Rotshenker

Abstract

The multifunctional cytokine interleukin 6 (IL-6) has direct growth, survival and differentiation effects on peripheral and central neurons. Furthermore, it can modulate the production by non-neuronal cells of other cytokines and growth factors, and thereby affect nerve cells indirectly. We have studied IL-6 expression and production in intact and injured peripheral nerves of C57/BL/6NHSD mice, which display the normal rapid progression of Wallerian degeneration. The IL-6 mRNA was detected in nerves degenerating in vitro or in vivo, but not in intact nerves. In vitro- and in vivo-degenerating nerve segments and neuroma nerve segments synthesized and secreted IL-6. The onset of IL-6 production was rapid and prolonged. It was detected as early as 2 h after injury and persisted for the entire period of 21 days tested after the injury. Of the non-neuronal cells that reside in intact and injured nerves, macrophages and fibroblasts were the major contributors to IL-6 production. We also studied IL-6 production in intact and injured nerves of mutant C57BL/6-WLD/OLA/NHSD mice, which display very slow progression of Wallerian degeneration. Injured nerves of C57BL/6-WLD/OLA/NHSD mice produced significantly lower amounts of IL-6 than did ...Continue Reading

References

Jun 1, 1992·Immunological Reviews·S Akira, T Kishimoto
Jul 1, 1992·Journal of Neuroimmunology·S RotshenkerV Barak
Mar 2, 1992·Neuroscience Letters·B SchöbitzE R De Kloet
Dec 1, 1990·Journal of Neuroimmunology·E N BenvenisteG M Fuller
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T HiranoT Kishimoto
Mar 1, 1988·The Journal of Experimental Medicine·M LotzD A Carson
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K IkebuchiM Ogawa
Apr 1, 1994·Journal of Neuroimmunology·B D GitterD C Waters
Sep 1, 1994·Journal of Neurochemistry·E D CadmanC M Lee
Feb 1, 1995·Journal of Neurochemistry·L M BolinJ S Abrams
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·M J Fann, P H Patterson
Nov 1, 1994·American Journal of Respiratory Cell and Molecular Biology·K M FriesR P Phipps
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangW N Rom
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·D J BenosE N Benveniste
Jan 1, 1989·The European Journal of Neuroscience·E R LunnS Gordon

❮ Previous
Next ❯

Citations

Mar 21, 2000·Journal of Neuroscience Research·M ThierS Rose-John
Jan 3, 2001·Seminars in Surgical Oncology·G R Evans
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Dec 14, 2004·Journal of Neurology·Jorge Correale, Andrés Villa
Nov 29, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Anandakumar ShunmugavelInderjit Singh
Jan 28, 2004·European Journal of Pharmacology·Sarah J L FlattersAnthony H Dickenson
Jun 7, 2005·Experimental Neurology·Lowell T McPhailWolfram Tetzlaff
Mar 17, 2004·Immunology Letters·Frank J P M HuygenFreek J Zijlstra
Dec 9, 2003·Journal of Neuroscience Methods·T Houalla, R L Levine
Mar 23, 2004·Molecular and Cellular Neurosciences·Julia JungnickelClaudia Grothe
Aug 23, 2003·Brain Research·Sarah J L FlattersAnthony H Dickenson
Nov 19, 2003·Clinics in Plastic Surgery·Gregory R D Evans
Nov 1, 1996·Journal of Neuroimmunology·F Reichert, S Rotshenker
Jan 8, 2000·Journal of Neuroimmunology·J Knezevic-CucaG L Pittenger
Jan 8, 2000·Journal of Neuroimmunology·H S TaskinenM Röyttä
Mar 10, 2001·Progress in Neurobiology·R KieferH P Hartung
Aug 1, 1997·Progress in Neurobiology·R A Gadient, U H Otten
Aug 5, 2000·Progress in Retinal and Eye Research·H K Yip, K F So
Oct 1, 1998·Cytokine & Growth Factor Reviews·R Kaempfer
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Eunjoo BaikKyungsoon Chung
Jun 24, 2011·Cell Death & Disease·R OharaT Yamashita
Oct 10, 1998·The European Journal of Neuroscience·H Be'eriS Rotshenker
Feb 4, 1999·Journal of Neurochemistry·N MadoreJ P Swerts
Apr 10, 2002·Journal of the Peripheral Nervous System : JPNS·Guido StollRobert R Myers
Dec 14, 2004·Tissue Engineering·Michael P McConnellGregory R D Evans
Apr 1, 1997·Brain Pathology·W Brück
Mar 8, 2007·Annual Review of Neuroscience·Zu-Lin ChenSidney Strickland
Sep 1, 2011·Journal of Neuroinflammation·Shlomo Rotshenker
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·P MärzS Rose-John
Jul 14, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ulrich Reinhart GoesslerFrank Riedel
Sep 30, 2014·International Journal of Molecular Sciences·Leah A GarciaMonica G Ferrini
Jun 3, 2009·Brain, Behavior, and Immunity·Eli EliavMichael Tal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.