Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas

International Journal of Cancer. Journal International Du Cancer
Yasuo AdachiNorihiro Nishimoto

Abstract

Malignant mesothelioma (MM), an incurable tumor, is reportedly an interleukin-6 (IL-6) secreting tumor. The pathological significance of IL-6 overexpression in this tumor, however, has remained unclear. We investigated the biological functions of IL-6 in mesotheliomas. Five mesothelioma cell lines were analyzed for IL-6 production and IL-6 receptor (IL-6R) expression. Of them, 2 produced high levels of IL-6, 2 produced intermediate levels and 1 cell line showed no secretion. All mesothelioma cell lines used in this study expressed very small amounts of IL-6R mRNA. We compensated for this low level of IL-6R expression in mesotheliomas by adding recombinant soluble IL-6R (sIL-6R) to mediate the IL-6 signal. IL-6 together with sIL-6R was found to promote cell growth of H2052 and H226 MMs classified as high-level IL-6 producers in a dose-dependent manner. Moreover, a humanized anti-IL-6R antibody (MRA) capable of blocking IL-6 signaling suppressed the cell growth of mesotheliomas induced by IL-6/sIL-6R. These findings demonstrate that IL-6 serves as an autocrine growth factor in the development of mesothelioma. In addition, IL-6/sIL-6R stimulation increased the expression of vascular endothelial growth factor (VEGF) in 4 out of 5 c...Continue Reading

References

Jun 1, 1982·Cancer·J BrennerR B Golbey
May 1, 1995·American Journal of Respiratory Cell and Molecular Biology·D R FitzpatrickH Bielefeldt-Ohmann
Apr 1, 1995·Cancer Immunology, Immunotherapy : CII·H Bielefeldt-OhmannD R Fitzpatrick
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·J B RubinsP Bitterman
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P McLaughlinB K Dallaire
Jul 15, 1999·Biochemical and Biophysical Research Communications·T Hirano
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·L MarklundK Grankvist
Feb 12, 2002·Seminars in Oncology·Michele CarboneJoseph R Testa
Nov 8, 2002·Biochimica Et Biophysica Acta·Simon A Jones, Stefan Rose-John
Feb 21, 2003·International Journal of Cancer. Journal International Du Cancer·Rizwan MasoodParkash S Gill
May 30, 2003·The Biochemical Journal·Peter C HeinrichFred Schaper
May 21, 2004·The New England Journal of Medicine·Nancy J Olsen, C Michael Stein

❮ Previous
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Citations

Jan 1, 2010·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Nathan R MiselisAgnes B Kane
Aug 28, 2009·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Indroneal BanerjeeTroy A Baudino
Sep 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Salahuddin AhmedAlisa E Koch
Jan 26, 2012·Pancreas·Katherine M BlockAmanda F Baker
Sep 3, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Hideki OguraMasaaki Murakami
May 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Arthur Kwok Leung CheungMaria Li Lung
Mar 1, 2008·Expert Review of Clinical Immunology·Toru Mima, Norihiro Nishimoto
Sep 15, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Renata AllevaMarco Tomasetti
Oct 4, 2013·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Katsunari Matsuoka
Mar 10, 2007·Cancer·Amie Y LeeDavid M Jablons
Apr 26, 2007·Medicinal Research Reviews·Zhong Chen, Zhong Chao Han
Aug 19, 2010·Annals of the New York Academy of Sciences·Jedd M HillegassBrooke T Mossman
Oct 16, 2010·International Journal of Cancer. Journal International Du Cancer·Kota IwahoriTetsuji Naka
Jul 22, 2008·The Annals of Thoracic Surgery·Harvey I PassSofia Merajver
Mar 11, 2015·Journal of Cellular Biochemistry·Julie DragonArti Shukla
May 4, 2012·Experimental Eye Research·Tohru SakimotoMitsuru Sawa
Oct 9, 2013·Expert Opinion on Therapeutic Targets·Shili Xu, Nouri Neamati
Feb 26, 2013·Cell Reports·Masaaki MurakamiToshio Hirano
Jul 19, 2011·Toxicology·Damiano CarbonariMonica Amati
Nov 12, 2016·Journal of the American Society of Nephrology : JASN·Rusan CatarAchim Jörres
Feb 22, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Sheree E Chen, Makala B Pace
Dec 19, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshinori NaritaTakashi Nishimura
Mar 25, 2017·Molecular Medicine Reports·Caterina LeddaCarla Loreto
Jan 24, 2019·Frontiers in Endocrinology·Danielle HarmerMichaela R Reagan
Dec 11, 2019·Cancers·Sadaf FarsinejadMarcin Iwanicki
Jun 29, 2012·Oncology Letters·Aki MurakamiTakashi Nakano

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