Interleukin 6 inhibits HBV entry through NTCP down regulation

Virology
Fidaa BouezzedinePhilippe Gripon

Abstract

Hepatitis B virus (HBV) infection is a major public health problem. Recently, the human liver bile acid transporter Na(+)/taurocholate cotransporting polypeptide (NTCP) has been identified as an HBV specific receptor. NTCP expression is known to be strongly regulated by IL-6. This study was aimed at characterizing the effect of IL-6 on HBV entry. HBV entry was inhibited by up to 90% when cells were pretreated with IL-6 as shown by a strong inhibition of long term HBsAg secretion. This effect was confirmed by showing a severe reduction of intracellular HBV cccDNA. In parallel, we observed a 98% decrease in NTCP mRNA steady state level and an 80% reduction in NTCP-mediated taurocholate uptake. IL-6-mediated inhibition of NTCP-mediated taurocholate uptake and viral entry exhibited similar dose-dependence and kinetics while restoration of NTCP expression suppressed the inhibitory effect of IL-6. NTCP-mediated HBV entry is therefore markedly inhibited by IL-6.

References

May 1, 1992·Journal of Clinical Immunology·Y SunH Obata
May 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D E CressmanR Taub
Feb 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D TorreR Tambini
Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·C Seeger, W S Mason
Nov 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Philippe GriponChristiane Guguen-Guillouzo
Jan 1, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Diana JungGerd A Kullak-Ublick
Jul 15, 2005·Journal of Virology·Stefan F Wieland, Francis V Chisari
Feb 21, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marc Le VeeOlivier Fardel
Nov 10, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marc Le VeeOlivier Fardel
Nov 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andreas SchulzeStephan Urban
Dec 17, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marc Le VeeOlivier Fardel
Apr 21, 2009·Journal of Biomedical Science·Tzer-Min KuoChungming Chang
Aug 8, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marc Le VeeOlivier Fardel
Sep 11, 2009·Journal of Virology·Charlotte Lepère-DouardPhilippe Gripon
Oct 23, 2009·Journal of Virology·Alina MacoveiNorica Branza Nichita
Nov 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marianna HöselUlrike Protzer
May 17, 2011·Biochemical Pharmacology·Marc Le VeeOlivier Fardel
Jul 20, 2011·Hepatology International·Corinna Jen-Hui PanDing-Shinn Chen
Sep 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andreas SchulzeStephan Urban
Feb 12, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gregory NoelOlivier Fardel
Feb 22, 2014·Science·Julie LuciforaUlrike Protzer
Apr 16, 2014·Journal of Gastroenterology and Hepatology·Hui-Lin WuChun-Jen Liu
Apr 29, 2014·Gastroenterology·Stephan UrbanFabien Zoulim

❮ Previous
Next ❯

Citations

Aug 13, 2015·International Journal of Molecular Sciences·Akinobu TakakiTakahito Yagi
Jan 20, 2016·Viruses·Dvora Witt-KehatiAmir Shlomai
Sep 22, 2015·Viruses·Lei KangJing Tang
Sep 29, 2015·Journal of Gastroenterology and Hepatology·C Nelson HayesKazuaki Chayama
Nov 3, 2015·Clinical and Molecular Hepatology·Jisu Li, Shuping Tong
Jun 14, 2015·Antiviral Research·Huan YanWenhui Li
Mar 15, 2016·Immunotherapy·Forough Golsaz-Shirazi, Fazel Shokri
Sep 23, 2016·Viruses·Eloi R VerrierThomas F Baumert
Apr 17, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ting YuanWei Li
Jan 25, 2017·Viruses·Yuchen Xia, Ulrike Protzer
Nov 20, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Senko TsukudaTakaji Wakita
Aug 10, 2018·The Journal of Clinical Investigation·Alice R BurtonMala K Maini
Jan 6, 2016·World Journal of Hepatology·Li WangZhi-Qiang Zou
Oct 27, 2016·Current Opinion in Infectious Diseases·Jiaqian PanJing Tang
Jul 24, 2018·Frontiers in Pharmacology·Qian-Qian ZhangFeng-Guo Xu
Jun 18, 2019·Pharmacological Reports : PR·Mateusz KurzawskiMarek Droździk
Nov 22, 2017·Digestive Diseases and Sciences·Jingwu DongMiaomiao Zhang
Mar 25, 2020·World Journal of Gastroenterology : WJG·Murali GanesanNatalia A Osna
Feb 12, 2020·ACG Case Reports Journal·Milan J SonneveldR A de Man
May 23, 2018·International Journal of Molecular Medicine·Hui CaoWei Zhang
May 28, 2019·Frontiers in Microbiology·Lauro Velazquez-SalinasManuel V Borca
Sep 25, 2019·Nature Reviews. Gastroenterology & Hepatology·Mala K Maini, Alice R Burton
Jan 14, 2020·Journal of Cellular and Molecular Medicine·Xiaoqiang YangXiaoling Zhou
Oct 23, 2020·Viral Immunology·Camilla Rodrigues de Almeida RibeiroVanessa Salete de Paula
Aug 10, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joannah R FergussonAndrew Knox
Dec 16, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Ann BiehlMark Avigan
Dec 6, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jinghang XuZheng Zeng
Jan 14, 2021·Virology Journal·Camilla Rodrigues de Almeida RibeiroVanessa Salete de Paula
Nov 12, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kira A A T LowjagaJoachim Geyer
Dec 23, 2019·Journal of Molecular Cell Biology·Xiaoqing ZhaoHua Tang
Jan 1, 2021·Frontiers in Immunology·Ying Cai, Wenwei Yin
Jun 3, 2021·International Journal of Molecular Sciences·Arshi KhanamShyam Kottilil
Aug 29, 2021·Viruses·Margaux J HeuschkelEloi R Verrier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis