PMID: 8953522Nov 1, 1996Paper

Interleukin-6, interferon-gamma, interleukin-8, and granulocyte-macrophage colony stimulating factor levels in human amniotic fluid at term

Journal of Reproductive Immunology
K S OláhP M Johnson

Abstract

Cytokines contribute to the maintenance of successful pregnancy and have also been implicated in the initiation of labour. This study has examined those cytokines which may be involved in normal term parturition. IL-6, IFN-gamma, IL-8 and GM-CSF levels were measured by ELISA in samples of amniotic fluid, peripheral and uterine venous blood plasma, and umbilical artery blood plasma from non-labouring women undergoing elective caesarean section at term and from women in spontaneous labour. IFN-gamma and IL-6 were detected only in amniotic fluid and not in blood plasma samples, unlike IL-8 which was found in all amniotic fluid and plasma samples from both labouring and non-labouring women; GM-CSF was undetectable in all samples examined. Levels of IL-6 were significantly raised in the amniotic fluid of women in labour compared with the control group (P = 0.008). IFN-gamma was detected in the amniotic fluid of both labouring women and the control group, and there was also a significant correlation (P = 0.003) between IFN-gamma and IL-6 levels in individual amniotic fluid samples. The presence of both IFN-gamma and IL-8 in amniotic fluid, as well as IL-6, suggests these cytokines are involved in important immunobiological events rel...Continue Reading

Citations

Jun 24, 2004·American Journal of Reproductive Immunology : AJRI·Nazeeh HannaSurendra Sharma
Apr 29, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Sabnavis SowmyaAnanthapur Venkateshwari
Feb 25, 2017·American Journal of Reproductive Immunology : AJRI·Nardhy Gomez-LopezSonia S Hassan
Jul 24, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C A JonesJ O Warner
May 29, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H FukudaT Ishimaru
Sep 5, 2001·Acta Obstetricia Et Gynecologica Scandinavica·G HebischR Huch
Jan 4, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Bogdan PanaitescuChaur-Dong Hsu
Mar 10, 2016·American Journal of Reproductive Immunology : AJRI·Roberto RomeroNardhy Gomez-Lopez
Jun 25, 2008·American Journal of Reproductive Immunology : AJRI·Yoon Kyong Choi, Joanne Kwak-Kim
Jan 2, 2007·Obstetrics and Gynecology·Amy P MurthaR Phillips Heine
Oct 30, 2020·Frontiers in Immunology·Vladimir Rogovskii
Apr 14, 2021·Journal of Reproductive Immunology·Mandy BusseAna Claudia Zenclussen
May 17, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jacek R Wilczyński
May 5, 2010·Biochimie·Jean-Pierre M'bikaCharles Chany

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