Interleukin-6, interleukin-8, and granulocyte elastase in newborns with fetal distress

Gynecologic and Obstetric Investigation
T HataM Kitao

Abstract

Our purpose was to investigate the participation of cytokines and neutrophils in fetal distress. Umbilical cord serum interleukin-6 (IL-6), interleukin-8 (IL-8), and plasma granulocyte elastase (GEL) were measured in 30 normally grown newborns without fetal distress (Group A), 10 growth-retarded newborns without acute fetal distress (Group B), 5 normally grown newborns with fetal distress (Group C), and 5 growth-retarded newborns with fetal distress (Group D). Umbilical arterial blood pH and PO2 were also measured. Umbilical arterial blood pH and PO2 in either Group C or Group D were significantly lower than those in either Group A or Group B. The concentration of IL-6 in Group D was significantly higher than that in either Group A, B, or C. The level of IL-8 in either Group C or Group D was significantly higher than that in either Group A or Group B. The concentrations of GEL in Group D was significantly higher than that in either Group A or Group B. This study suggests that fetal distress in utero causes an elevation of immune factors such as IL-6, IL-8 and GEL.

Citations

Aug 23, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Y KoumantakiE Koumantakis
Mar 21, 2003·Pediatric Research·Douglas E LakeJ Randall Moorman
Jul 14, 2006·American Journal of Reproductive Immunology : AJRI·Andrea SteinbornEdgar Schmitt
Oct 26, 2005·Biology of the Neonate·Kaoru OkazakiHirokazu Kimura
Jan 3, 2013·American Journal of Reproductive Immunology : AJRI·Edward MullinsSailesh Kumar

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