Interleukin-6: Its role and mechanisms in rescuing depression-like behaviors in rat models of depression

Brain, Behavior, and Immunity
Peng WangShu Yan Yu

Abstract

Neuronal injury within specific brain regions is considered a critical risk factor in the pathophysiology of depression. However, the underlying mechanisms of this process, and thus the potential for development of novel therapeutic strategies in the treatment of depression, remain largely unknown. Here, we report that Il-6 protects against neuronal anomalies related with depression, in part, by suppressing oxidative stress and consequent autophagic and apoptotic hyperactivity. Specifically, we show that IL-6 is downregulated within the CA1 hippocampus in two animal models of depression and upregulated by antidepressants. Increasing levels of IL-6 in the CA1 region result in pleiotropic protective actions including reductions in oxidative stress and modulation of autophagy, anti-immuno-inflammatory activation and anti-apoptotic effects in CA1 neurons, all of which are associated with the rescue of depression-like behaviors. In contrast, IL-6 downregulation exacerbates neuronal anomalies within the CA1 region and facilitates the genesis of depression phenotypes in rats. Interestingly, in addition to attenuating oxidative damage, the antioxidant, N-acetylcysteine (NAC), is also associated with significantly decreased neuronal def...Continue Reading

Citations

Aug 28, 2020·International Journal of Molecular Sciences·Filip JovanovicNebojsa Nick Knezevic
Sep 29, 2020·Experimental Neurology·Bruna C PieroneManuella P Kaster
Jun 22, 2021·American Journal of Respiratory Cell and Molecular Biology·Martin Witzenrath, Wolfgang M Kuebler
Nov 13, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Cuiqin FanShu Yan Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.