Interleukin-6, its role in fibrosing conditions

Cytokine & Growth Factor Reviews
Steven O'ReillyJacob M van Laar

Abstract

Interleukin-6 is a classic pro-inflammatory cytokine needed to mount an effective immune response. It is secreted by a wide array of cell types, however, its target cells are more restricted, due to the fact that very few cells, except lymphocytes and hepatocytes, express the functional membrane IL-6 receptor. This therefore limits the amount of cells that can respond to IL-6. Transsignalling, the shedding of the membrane bound form of the IL-6 receptor (sIL-6R) into the local microenvironment, greatly increases the range of cells that can respond e.g. as part of a wound healing response necessary to restore the homeostatic balance. Therefore, tight regulation of IL-6 signalling must occur to stop an inappropriate wound healing response occurring. This review focusses on the role of IL-6 in inflammation and fibrosing conditions, with a particular emphasis on systemic sclerosis (SSc), a chronic autoimmune disease in which a classical hallmark of fibrosis occurs. This fibrosis, in particular the skin and internal organs, leads to contractures and internal organ failure respectively with potential fatal consequences. In this review we will discuss the biology of IL-6 in the context of fibrosing conditions such as SSc and argue why...Continue Reading

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Citations

Jun 19, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Kathrin AicheleMartin Oberringer
Aug 30, 2013·Expert Reviews in Molecular Medicine·Marzena CiechomskaSteven O'Reilly
Apr 1, 2013·Clinical & Translational Immunology·Steven O'ReillyJacob M van Laar
Jul 26, 2013·BMC Bioinformatics·Panagiotis MoulosJoost P Schanstra
Oct 1, 2013·Pharmacology & Therapeutics·Xin YaoYihong Yao
Jul 18, 2014·Genes and Immunity·M CiechomskaS O'Reilly
Aug 31, 2016·Burns and Trauma·Zhensen ZhuEdward E Tredget
Oct 31, 2012·Cytokine & Growth Factor Reviews·Parvin Ataie-KachoieDavid L Morris
Dec 26, 2015·Fish & Shellfish Immunology·J G SchmidtM E Nielsen
Jun 7, 2013·Arthritis and Rheumatism·Augusto VaglioCarlo Salvarani
Feb 26, 2015·Experimental Dermatology·Marzena CiechomskaSteven O'Reilly
Jul 23, 2015·Science Signaling·Zhaoyang LiuMatthew J Hilton
Jul 15, 2015·Seminars in Immunopathology·Nicola Fullard, Steven O'Reilly
Jul 11, 2014·PLoS Neglected Tropical Diseases·Tiffany WeinkopffPatrick J Lammie
Sep 22, 2016·Scientific Reports·Akihito UeharaOsamu Ishikawa
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Feb 13, 2017·Cell and Tissue Research·Anke NijhuisAndrew Silver
Jun 21, 2020·Current Rheumatology Reports·Monique Hinchcliff, Steven O'Reilly
Jun 25, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Zhiwei XuMingcai Li
Aug 5, 2017·Frontiers in Pharmacology·Kelly L WaltonCraig A Harrison
Oct 31, 2020·Journal of Cellular and Molecular Medicine·Małgorzata GałdyszyńskaJacek Drobnik
Jan 12, 2021·Free Radical Biology & Medicine·Sabira MohammedSathyaseelan S Deepa
Sep 5, 2021·Nature Reviews. Rheumatology·Pei-Suen TsouSteven O'Reilly

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