Interleukin 6 mediated differentiation and rescue of cell redox in PC12 cells exposed to ionizing radiation

FEBS Letters
K AbeyamaI Maruyama

Abstract

The differentiation of PC12 cells to a neuron-like morphology was induced by ionizing radiation in the presence of serum. This effect was detectable at 5 grays (Gy) and reached a maximum at 10-20 Gy. Increases in the DNA binding activity of nuclear factor kappa B (NF-kappa B) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy. Neutralization of supernatant IL-6 by the addition of anti-IL-6 antibody inhibited the neuronal differentiation and decreased cellular redox. Ionizing radiation and serum may act synergistically as neurotropic factors.

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Citations

Oct 3, 2001·International Journal of Cancer. Journal International Du Cancer·Y HosoiT Ono
Aug 10, 2007·Inflammation·Yamini B TripathiBahram H Arjmandi
Mar 7, 2001·Antioxidants & Redox Signaling·B KaltschmidtC Kaltschmidt
Jun 28, 2008·Radiation and Environmental Biophysics·Takahiro KuchimaruToshiyuki Iida
Apr 29, 2015·International Journal of Radiation Biology·Hyeon Soo EomUhee Jung
Jan 23, 2004·Journal of Pharmacological Sciences·Naoko ShimmaToshihiko Murayama
Sep 10, 2003·Journal of Leukocyte Biology·Kazuhiro AbeyamaIkuro Maruyama
Jun 30, 2004·Radiation Research·William H McBrideYu-Pei Liao
May 17, 2017·Molecular Neurobiology·Yanuar Alan SulistioKlaus Heese
Jan 18, 2011·Brain Research Reviews·Anneleen SpoorenSarah Gerlo

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