Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model

Pain
Dong FangGuo-Gang Xing

Abstract

Primary and metastatic cancers that affect bone are frequently associated with severe and intractable pain. The mechanisms underlying the pathogenesis of bone cancer pain still remain largely unknown. Previously, we have reported that sensitization of primary sensory dorsal root ganglion (DRG) neurons contributes to the pathogenesis of bone cancer pain in rats. In addition, numerous preclinical and clinical studies have revealed the pathological roles of interleukin-6 (IL-6) in inflammatory and neuropathic hyperalgesia. In this study, we investigated the role and the underlying mechanisms of IL-6 in the development of bone cancer pain using in vitro and in vivo approaches. We first demonstrated that elevated IL-6 in DRG neurons plays a vital role in the development of nociceptor sensitization and bone cancer-induced pain in a rat model through IL-6/soluble IL-6 receptor (sIL-6R) trans-signaling. Moreover, we revealed that functional upregulation of transient receptor potential vanilloid channel type 1 (TRPV1) in DRG neurons through the activation of Janus kinase (JAK)/phosphatidylinositol 3-kinase (PI3K) signaling pathway contributes to the effects of IL-6 on the pathogenesis of bone cancer pain. Therefore, suppression of funct...Continue Reading

References

Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W J Dixon
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Mar 24, 1999·Journal of Immunological Methods·T JostockJ Müllberg
Dec 20, 2000·European Journal of Biochemistry·T JostockS Rose-John
Nov 8, 2001·European Journal of Pharmacology·M Zimmermann
Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhi-Ye ZhuangRu-Rong Ji
Mar 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joseph R GhilardiPatrick W Mantyh
Apr 9, 2005·Experimental Neurology·Christopher M PetersPatrick W Mantyh
Jun 15, 2005·Journal of Neurochemistry·Gisela Segond von BanchetHans-Georg Schaible
Dec 2, 2005·The EMBO Journal·Xuming ZhangPeter A McNaughton
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaochun Jin, Robert W Gereau
Apr 28, 2006·Scandinavian Journal of Immunology·J SchellerS Rose-John
May 19, 2006·Journal of Leukocyte Biology·Stefan Rose-JohnSimon A Jones
Jul 14, 2006·Pflügers Archiv : European journal of physiology·Tomoya MatsutomiNobukuni Ogata
Nov 1, 2006·The Journal of General Physiology·Alexander T SteinSharona E Gordon
Sep 14, 2007·Molecular and Cellular Neurosciences·Susanne HensellekGisela Segond von Banchet
Apr 9, 2008·Nature Neuroscience·Man-Kyo ChungMichael J Caterina
May 9, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cristina E ConstantinMichaela Kress
Sep 9, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·T R NeelandsC S Surowy
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander M BinshtokTarek A Samad
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Manfred AndratschMichaela Kress
Apr 8, 2010·Journal of Anesthesia·Tomoyuki KawamataShingo Furuse
Apr 14, 2010·Pain Practice : the Official Journal of World Institute of Pain·Ricardo VallejoRamsin Benyamin
Apr 20, 2010·Annals of the New York Academy of Sciences·H-G SchaibleG Natura
Aug 17, 2010·Pain·Marianne Neves ManjavachiJoão B Calixto
Oct 29, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jalal A JazayeriGraeme J Carroll
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ohannes K MelemedjianTheodore J Price
Dec 15, 2010·European Journal of Cell Biology·Athena ChalarisJürgen Scheller
Jan 18, 2011·Brain Research Reviews·Anneleen SpoorenSarah Gerlo

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Citations

May 21, 2016·Frontiers in Physiology·Sara Nencini, Jason J Ivanusic
Feb 13, 2020·Frontiers in Immunology·Gilson Gonçalves Dos SantosMaripat Corr
May 21, 2020·Frontiers in Pharmacology·Bing YangDongxin Tang
Oct 22, 2018·Current Osteoporosis Reports·Toshiyuki YonedaTatsuo Okui
Dec 5, 2019·Frontiers in Neuroscience·Masamichi ShinodaKoichi Iwata
Jun 27, 2017·Frontiers in Physiology·Isaac JardínJuan A Rosado
Sep 29, 2017·Frontiers in Neurology·Jason J Ivanusic
Oct 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia SunDa-Wei Ye
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mayur J PatilArmen N Akopian
Dec 29, 2019·British Journal of Pharmacology·Chengyu YinBoyi Liu
Feb 15, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Franz NürnbergerJoachim Roth
Dec 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ho-Sung LeeDae-Yeon Lee
Feb 23, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Stephan LeisengangJoachim Roth
Mar 13, 2021·Open Access Rheumatology : Research and Reviews·Anthony Sebba
Jan 15, 2021·Zeitschrift für Rheumatologie·G Pongratz
Mar 31, 2021·Rheumatic Diseases Clinics of North America·Ejaz M I Pathan, Robert D Inman
Apr 25, 2018·Journal of Neuroimmunology·Kenichi SerizawaYoshihiro Matsumoto
Jun 8, 2021·Frontiers in Molecular Neuroscience·Baowen LiuGuangyou Duan
May 8, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Qing-Qing YangXiao-Yan Zeng
Aug 20, 2021·Cytokine·Robert H JenkinsSimon A Jones

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