Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation

Molecular Neurobiology
Yanuar Alan SulistioKlaus Heese

Abstract

In an aging society with an increasing threat to higher brain cognitive functions due to dementia, it becomes imperative to identify new molecular remedies for supporting adult neurogenesis. Interleukin-6 (IL-6) is a promising cytokine that can support neurogenesis under conditions of neurodegeneration, and neuron replacement is eventually possible due to its agonistic acting soluble receptor sIL-6R. Here, we report that activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis is neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease (PD).

References

Jul 8, 1988·Neuroscience Letters·J M ShenA R Kriegstein
Jan 1, 1997·Annual Review of Immunology·T Taga, T Kishimoto
Mar 28, 1998·The European Journal of Neuroscience·P MärzS Rose-John
Jul 1, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K H SchäferS Rose-John
Oct 6, 1999·The European Journal of Neuroscience·P MärzS Rose-John
Mar 21, 2000·Journal of Neuroscience Research·M ThierS Rose-John
Sep 5, 2002·Nature Reviews. Neuroscience·David F Owens, Arnold R Kriegstein
Oct 2, 2002·The Journal of Comparative Neurology·Susanne PetriThomas Arzberger
May 7, 2004·The European Journal of Neuroscience·Ron C HoggDavid J Adams
May 7, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William B J CaffertyStephen W N Thompson
Oct 23, 2004·Experimental Neurology·Eric Herlenius, Hugo Lagercrantz
Dec 14, 2004·Neuroscience·R LujánG López-Bendito
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Sep 1, 2005·Clinical Reviews in Allergy & Immunology·Tetsuya Taga, Shinji Fukuda
Jan 13, 2006·The Journal of Cell Biology·Dominic Chi Hiung NgXinmin Cao
Apr 14, 2006·The Journal of Biological Chemistry·Yu Pong NgNancy Y Ip
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M Austin JohnsonSu-Chun Zhang
May 15, 2007·Progress in Brain Research·James M Tepper, Christian R Lee
May 2, 2008·Stem Cells and Development·Kara M Foshay, G Ian Gallicano
Aug 14, 2008·Nature Reviews. Molecular Cell Biology·Shin-ichi NishikawaConcepcion R Nierras
Oct 31, 2008·Molecular Biology of the Cell·Omedul IslamKlaus Heese
Jun 27, 2009·Annual Review of Neuroscience·Arnold Kriegstein, Arturo Alvarez-Buylla
Mar 23, 2010·Biochemical and Biophysical Research Communications·Fang CaoMasahiro Sakanaka
Aug 19, 2010·Journal of Cellular and Molecular Medicine·Manisha MishraKlaus Heese
Jan 5, 2011·Journal of Cellular and Molecular Medicine·Manisha Mishra, Klaus Heese
Jan 27, 2011·Neuroreport·Kellie K BowenRaghu Vemuganti
Apr 5, 2011·Nature Methods·Keisuke OkitaShinya Yamanaka
Sep 14, 2011·Journal of Neuroscience Methods·Danielle Guez-BarberBruce T Hope

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Methods Mentioned

BETA
Transfection
fluorescence-activated cell sorting
FACS
Flow Cytometry

Software Mentioned

FlowJo
FACS Diva

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