Interleukin-6 mediates hepatic hypersecretion of apolipoprotein B.

American Journal of Physiology. Gastrointestinal and Liver Physiology
Janet D SparksCharles E Sparks

Abstract

Obesity and type 2 diabetes are associated with insulin resistance (IR), increased circulating proinflammatory cytokines, and hypertriglyceridemia, the latter being caused by overproduction of hepatic very low density lipoprotein (VLDL). One cytokine strongly linked with development of hepatic IR is interleukin-6 (IL-6). Our objective was to evaluate IL-6 effects on hepatic apolipoprotein B (apoB) and VLDL secretion and to examine possible linkages between cytokine signaling and insulin-suppressive effects on lipoprotein secretion. Of the cytokines examined, only IL-6 stimulated secretion of apoB-containing lipoproteins in a dose-dependent manner. Both B100 and B48 secretion were significantly increased in VLDL and in lipoproteins with a density >1.019 g/ml. The ability of insulin to suppress hepatic apoB secretion was maintained in hepatocytes treated with IL-6. Pulse-chase studies indicated that enhanced apoB synthesis was the primary mechanism for increased lipoprotein secretion, which corresponded with higher abundance of apoB mRNA. Because IL-6 did not alter the decay rate of apoB mRNA transcripts, results support that increased apoB mRNA levels are the result of enhanced apob gene transcription. Increased apoB-lipoprotein...Continue Reading

References

Nov 17, 1994·Biochimica Et Biophysica Acta·J D Sparks, C E Sparks
Jun 1, 1994·Metabolism: Clinical and Experimental·J D SparksC E Sparks
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·W H EttingerR B Verdery
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·H BaumannL A Tartaglia
Sep 1, 1996·Metabolism: Clinical and Experimental·T L PhungH C Smith
Mar 7, 2001·Frontiers in Bioscience : a Journal and Virtual Library·V I ZannisD Kardassis
Apr 4, 2001·The Journal of Biological Chemistry·E A FisherK J Williams
Nov 28, 2002·Diabetes·Joseph J SennRobert A Mooney
May 30, 2003·The Biochemical Journal·Peter C HeinrichFred Schaper
Sep 27, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Priya RamanMichael E Spurlock
Feb 19, 2004·American Journal of Physiology. Endocrinology and Metabolism·Doru V ChirieacCharles E Sparks
Jul 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kohjiro UekiC Ronald Kahn
Sep 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Feng HongBin Gao
Feb 18, 2005·Journal of Lipid Research·Patricia AspichuetaOlatz Fresnedo
May 28, 2005·Circulation Research·Yi-Hao Yu, Henry N Ginsberg
Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Feb 14, 2006·The American Journal of Clinical Nutrition·Andrew S Greenberg, Martin S Obin
Jun 27, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Doru V ChirieacJanet D Sparks
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Sep 9, 2006·Endocrinology and Metabolism Clinics of North America·Tina J Chahil, Henry N Ginsberg
Oct 3, 2006·Trends in Endocrinology and Metabolism : TEM·Jane K Howard, Jeffrey S Flier
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Mar 31, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Takashi KosoneMasatomo Mori
Jun 19, 2007·The Journal of Biological Chemistry·Xiaoyue Pan, M Mahmood Hussain
Mar 29, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bolin QinKhosrow Adeli
May 24, 2008·The Journal of Clinical Investigation·Janet D Sparks, Charles E Sparks
May 24, 2008·The Journal of Clinical Investigation·Adama KamagateH Henry Dong
Jun 21, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Martin AdielsJan Borén
Oct 31, 2008·Endocrine Reviews·Marc-Andre CornierRobert H Eckel

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Citations

Feb 21, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Viviane de Oliveira Leal, Denise Mafra
Jan 24, 2012·Clinics and Research in Hepatology and Gastroenterology·Maria-Angeles AllerJaime Arias
Nov 20, 2012·Biochemical and Biophysical Research Communications·Jeffrey M ChamberlainJanet D Sparks
Feb 26, 2013·Diabetes·Christina KoutsariMichael D Jensen
Mar 13, 2012·Medical Hypotheses·María-Angeles AllerJaime Arias
Jul 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Janet D SparksKhosrow Adeli
Jun 23, 2011·American Journal of Physiology. Endocrinology and Metabolism·Changting XiaoGary F Lewis
Oct 20, 2018·Expert Opinion on Therapeutic Targets·Yoon Jin Cha, Ja Seung Koo

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Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

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