Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components.

Infection and Immunity
D DelfinoG Teti

Abstract

In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor necrosis factor alpha independent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus in monocytic cells, these findings may be clinically relevant.

References

May 1, 1990·Immunology Today·Z F Rosenberg, A S Fauci
Jan 1, 1990·Annual Review of Immunology·J Van Snick
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L OsbornG J Nabel
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J Van SnickR J Simpson
Jun 1, 1982·Journal of Bacteriology·E S JacobsonC C Nicholas

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Citations

May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M CuzzolaG Teti
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S ShohamS M Levitz
Jan 19, 2016·Frontiers in Cellular and Infection Microbiology·Makoto UraiYoshitsugu Miyazaki
Jan 1, 2020·Current Protein & Peptide Science·Laura C García-CarneroAlma K Tamez-Castrellón
Sep 29, 2020·Frontiers in Immunology·Ebru KarasuRebecca Halbgebauer
Feb 24, 2001·Medical Mycology·A Vecchiarelli
Feb 15, 2013·The Journal of Biological Chemistry·Christian HeissTamara L Doering
Apr 9, 2001·Infection and Immunity·D PietrellaA Vecchiarelli
Dec 18, 2013·Eukaryotic Cell·Juliana RizzoMarcio L Rodrigues
Apr 21, 2007·Microbiology and Immunology·Cilmery Suemi KurokawaMaria Terezinha S Peraçoli
Dec 21, 2016·European Journal of Immunology·Luca PangrazziBeatrix Grubeck-Loebenstein
Jul 28, 2020·Journal of Fungi·Man Shun Fu, Rebecca A Drummond
Nov 30, 2000·Current Infectious Disease Reports·A V Jacobs, H L Leaf
Jan 27, 2018·Journal of Fungi·Brendan D SnarrDonald C Sheppard
Jul 6, 2019·Frontiers in Medicine·Debora Decote-RicardoCelio Geraldo Freire-de-Lima
Jul 7, 2021·Medical Microbiology and Immunology·Aline Beatriz Mahler PereiraAlexandre Paula Rogerio

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