Interleukin-6 significantly improves predictive value of systemic inflammatory response syndrome for predicting severe acute pancreatitis.

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Saransh JainPramod Kumar Garg

Abstract

Predicting severe acute pancreatitis (AP) is important for triage, prognosis, and designing therapeutic trials. Persistent systemic inflammatory response syndrome (SIRS) predicts severe AP but its diagnostic accuracy is suboptimal. Our objective was to study if cytokine levels could improve the predictive value of clinical variables for the development of severe AP. Consecutive patients with AP were included in a prospective cohort study at a tertiary care center. Serum levels of IL-6, TNF-α, IL-10, MCP-1, GM-CSF and IL-1β were measured at day 3 of onset of AP. Variables such as age, co-morbidity, etiology, SIRS, and cytokines were modeled to predict severe AP by multivariable regression analysis. Genotyping was done to correlate IL-6, TNF-α and MCP-1 gene polymorphisms with cytokine levels. Of 236 patients with AP, 115 patients admitted within 7 days of onset formed the study group. 37 of the 115 (32%) patients developed organ failure. Independent predictors of organ failure were persistent SIRS (OR 34; 95% CI: 7.2-159) and day 3 serum IL-6 of >160 pg/ml (OR 16.1; 95% CI:1.8-142). IL-6 gene (-174 G/C) GG genotype was associated with significantly higher levels of IL-6 compared to CC/CG genotype. Serum IL-6 >160 pg/ml increased...Continue Reading

Citations

Mar 22, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruling ZhangJing Xue
Feb 6, 2020·International Journal of Molecular Sciences·Ana Ferrero-AndrésEmma Folch-Puy
Jun 21, 2020·International Journal of Molecular Sciences·Pedro Silva-VazJosé Guilherme Tralhão
May 3, 2019·BMC Gastroenterology·Jianhua WanNonghua Lu
Feb 16, 2019·Gastroenterology·Pramod K Garg, Vijay P Singh

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