PMID: 8613706Apr 1, 1996Paper

Interleukin-6 stimulates neutrophil production of platelet-activating factor

Journal of Leukocyte Biology
W L BifflV M Peterson

Abstract

Interleukin-6 (IL-6) is an integral mediator of the acute phase response to injury and infection; an exaggerated IL-6 response has been associated with adverse clinical events. The precise role of IL-6 is unclear, but it appears capable of modulating the functional repertoire of mature neutrophils (PMNs). Our previous work demonstrated that IL-6 -stimulated PMNs are primed by lower concentrations of platelet-activating factor (PAF) than nonstimulated PMNs. Recently, we have found that IL-6 suppresses PMN apoptosis via a PAF-like mechanism. We hypothesized that IL-6 stimulates PMNs to produce PAF. PMNs isolated from healthy human donors were incubated with IL-6 (0.1-100 ng/ml) at 37 degrees C. Lipid production was measured by use of thin-layer chromatography, and PAF quantitated with a scintillation proximity assay. IL-6 (1 and 10 ng/ml) stimulated PMNs to produce increase quantities of PAF. PAF production was associated with an increase in PMN cytosolic calcium. These data may provide mechanistic insight into IL-6 regulation of PMN-mediated cytotoxicity and the role of PAF in mediating IL-6 effects on PMNs.

Citations

Dec 6, 1997·Annals of Surgery·D R MeldrumA H Harken
Jul 8, 2011·Clinical Microbiology Reviews·Barry B Mook-KanamoriDiederik van de Beek
Oct 17, 1998·Journal of Veterinary Internal Medicine·D J Weiss, J Rashid
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Mar 29, 2001·Transfusion·M A Popovsky, R D Davenport
Nov 17, 2007·Journal of Applied Physiology·Shlomit Radom-AizikDan M Cooper
May 26, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M LoebeR Hetzer
Jun 27, 2020·Frontiers in Microbiology·Muhammad Suleman RiazAnsar Ahmed Pathan
Nov 8, 2017·Molecular Immunology·Osk U U AnuforoJona Freysdottir

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