Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension

Pulmonary Circulation
Levi D MastonLaura V Gonzalez Bosc

Abstract

Interleukin-6 (IL-6) is a pleotropic cytokine that signals through the membrane-bound IL-6 receptor (mIL-6R) to induce anti-inflammatory ("classic-signaling") responses. This cytokine also binds to the soluble IL-6R (sIL-6R) to promote inflammation ("trans-signaling"). mIL-6R expression is restricted to hepatocytes and immune cells. Activated T cells release sIL-6R into adjacent tissues to induce trans-signaling. These cellular actions require the ubiquitously expressed membrane receptor gp130. Reports show that IL-6 is produced by pulmonary arterial smooth muscle cells (PASMCs) exposed to hypoxia in culture as well as the medial layer of the pulmonary arteries in mice exposed to chronic hypoxia (CH), and IL-6 knockout mice are protected from CH-induced pulmonary hypertension (PH). IL-6 has the potential to contribute to a broad array of downstream effects, such as cell growth and migration. CH-induced PH is associated with increased proliferation and migration of PASMCs to previously non-muscularized vessels of the lung. We tested the hypothesis that IL-6 trans-signaling contributes to CH-induced PH and arterial remodeling. Plasma levels of sgp130 were significantly decreased in mice exposed to CH (380 mmHg) for five days comp...Continue Reading

References

Oct 1, 1989·The Journal of Experimental Medicine·D NovickM Rubinstein
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·M HumbertD Emilie
Jun 1, 1994·The Biochemical Journal·S Rose-John, P C Heinrich
Aug 26, 1998·The Biochemical Journal·P C HeinrichL Graeve
Sep 21, 2000·The Journal of Clinical Investigation·N F Voelkel, R M Tuder
Dec 20, 2000·European Journal of Biochemistry·T JostockS Rose-John
Jul 10, 2003·The Journal of Surgical Research·Zhongbiao Wang, Walter H Newman
May 6, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Simon A JonesStefan Rose-John
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rachel M McLoughlinSimon A Jones
Aug 22, 2006·Proceedings of the American Thoracic Society·Saadia EddahibiSerge Adnot
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva M BrisoMercedes Rincon
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Dec 17, 2008·Circulation Research·M Kathryn SteinerAaron B Waxman
Jan 29, 2009·Respiratory Research·Laurent SavaleSaadia Eddahibi
Jun 2, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nikki L JerniganThomas C Resta
Sep 15, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kurt R StenmarkIvan F McMurtry
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gareth W JonesSimon A Jones
Jun 29, 2010·European Journal of Immunology·Akihiro Kimura, Tadamitsu Kishimoto
Feb 8, 2011·Biochimica Et Biophysica Acta·Jürgen SchellerStefan Rose-John
Sep 2, 2011·The Journal of Clinical Investigation·Simon A JonesStefan Rose-John
Sep 13, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·R BiererL V Gonzalez Bosc
Nov 9, 2012·International Journal of Biological Sciences·Stefan Rose-John
Jan 22, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Larissa A Shimoda, Steven S Laurie
Mar 12, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Juan Manuel Ramiro-DiazLaura V Gonzalez Bosc
May 15, 2013·The FEBS Journal·Pura Muñoz-CánovesAntonio L Serrano
Nov 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Carlos H NittaNikki L Jernigan
Dec 12, 2013·Seminars in Immunology·Jürgen SchellerStefan Rose-John
Aug 20, 2014·Nature Reviews. Rheumatology·Leonard H Calabrese, Stefan Rose-John
Jan 22, 2015·International Journal of Cancer. Journal International Du Cancer·Freya A GoumasHolger Kalthoff
Mar 10, 2015·Current Opinion in Immunology·Christoph GarbersStefan Rose-John
Apr 22, 2015·Nature Immunology·Christopher A Hunter, Simon A Jones
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Takahiro Hashimoto-KataokaYoshikazu Nakaoka
Feb 19, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Levi D MastonLaura V Gonzalez Bosc

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Citations

May 6, 2019·Expert Opinion on Therapeutic Targets·Thomas BerteroStephen Y Chan
Jun 13, 2019·International Journal of Hypertension·Daniela Maria TanaseMariana Floria
Oct 1, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joshua R SheakLaura V Gonzalez Bosc
Nov 15, 2020·Basic Research in Cardiology·Mehreen BatoolHenrik Ten Freyhaus
Apr 10, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hui XuHongwei Wang
Apr 30, 2021·Frontiers in Cardiovascular Medicine·Srikanth KarnatiSüleyman Ergün

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