PMID: 7545370Jul 21, 1995Paper

Interleukin-6-type cytokine-induced changes in acute phase protein glycosylation

Annals of the New York Academy of Sciences
W Van Dijk, A Mackiewicz

Abstract

The plasma levels and the glycosylation of acute-phase proteins (APP) are subject to marked changes during acute and chronic inflammation. The pathophysiological variations in different glycoforms of APP in serum most likely result from changes in the glycosylation process during their biosynthesis in the parenchymal cells of the liver. This is suggested from in vitro studies with isolated hepatocytes and hepatoma cell lines. Inflammatory cytokines appear to regulate the changes in glycosylation independent from the rate of synthesis of the APP. In addition, other humoral factors like corticosteroids and growth factors are involved. The interplay of these factors is determined by the stage of the disease (as in rheumatoid arthritis) or the physiological situation (as in pregnancy). The changes in glycosylation of specific APP might affect the operation of the immune system.

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Citations

Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Jan 31, 2002·Arthritis and Rheumatism·Peter OlofssonRikard Holmdahl
Mar 25, 2017·Expert Opinion on Drug Metabolism & Toxicology·Sharon M SeifertPeter L Anderson
Sep 12, 2020·Journal of Clinical Medicine·Agnieszka GrytczukLech Chrostek
Sep 23, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M GulumianJ Murray
Jan 15, 2020·Nature Reviews. Rheumatology·Frauke Förger, Peter M Villiger
Oct 29, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·F HervéM C Jaurand
Sep 24, 2002·Biosensors & Bioelectronics·Mathias LiljebladPeter Påhlsson
Jun 3, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Shanshan ZhuChen Ding
Jul 19, 2016·Journal of Proteome Research·Barbara AdamczykPauline M Rudd

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